Blues in the brain and beyond: Molecular bases of major depressive disorder and relative pharmacological and non-pharmacological treatments

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite the extensive research conducted in recent decades, the molecular mechanisms underlying major depressive disorder (MDD) and relative evidence-based treatments remain unclear. Various hypotheses have been successively proposed, involving different biological systems. This narrative review aims to critically illustrate the main pathogenic hypotheses of MDD, ranging from the historical ones based on the monoaminergic and neurotrophic theories, through the subsequent neurodevelopmental, glutamatergic, GABAergic, inflammatory/immune and endocrine explanations, until the most recent evidence postulating a role for fatty acids and the gut microbiota. Moreover, the molecular effects of established both pharmacological and non-pharmacological approaches for MDD are also reviewed. Overall, the existing literature indicates that the molecular mechanisms described in the context of these different hypotheses, rather than representing alternative ones to each other, are likely to contribute together, often with reciprocal interactions, to the development of MDD and to the effectiveness of treatments, and points at the need for further research efforts in this field.

Original languageEnglish
Article number1089
Pages (from-to)1-24
Number of pages24
JournalGenes
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Antidepressant drugs
  • Brain-derived neurotrophic factor
  • Electroconvulsive therapy
  • Inflammation
  • Major depressive disorder
  • Monoamines
  • Neurotrophins
  • Non-pharmacological treatments
  • Serotonin

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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