Blunting of atrial natriuretic factor response to volume expansion by benazepril in hypertensive patients

Paolo Dessì-Fulgheri, Mario Motolese, Giorgio Di Noto, Domenico Delfino, Gilberta Giacchetti, Cesare Boria, [No Value] Alessandro

Research output: Contribution to journalArticlepeer-review

Abstract

To verify the hypothesis that the angiotensin converting enzyme (ACE) level may affect the metabolism of circulating atrial natriuretic factor (ANF), the acute and chronic effects of benazepril on plasma ANF levels were studied in hypertensive patients under basal conditions and in response to acute volume expansion. Ten essential hypertensives entered a double-blind crossover study, and were randomly allocated either to placebo or to 10 mg benazepril orally once a day for 2 days; after a placebo washout period of 2 days the groups were crossed over. On the second day of each crossover period, volume expansion was induced by infusing 1 litre saline in 30min, and blood samples for ANF measurements were drawn at times -5, 0, 5, 15, 30, 35, 40, 50 and 60min. Oral benazepril at 10 mg/day was then given to all patients for 4 weeks, and the volume expansion with saline was repeated. After the 2-day acute benazepril treatment, blood pressure fell from 166.1 ± 3.6/105.1 ± 0.9 to 140.1 ± 4.6/85.6 ± 2.1 mmHg (P <0.01 for both systolic and diastolic blood pressure), whereas ANF fell from 29.4 ± 3.6 to 24.1 ± 3.7 pg/ml (NS) after the acute benazepril treatment and to 17.7 ± 3.6 pg/ml (P

Original languageEnglish
Pages (from-to)S300-S301
JournalJournal of Hypertension, Supplement
Volume7
Publication statusPublished - 1989

Keywords

  • Angiotensin converting enzyme
  • Atrial natriuretic factor
  • Benazepril
  • Blood pressure
  • Volume expansion

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

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