Blys upregulation in Sjö gren's syndrome associated with lymphoproliferative disorders, higher ESSDAI score and B-cell clonal expansion in the salivary glands

Luca Quartuccio, Sara Salvin, Martina Fabris, Marta Maset, Elena Pontarini, Miriam Isola, Salvatore De Vita

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Primary SS is characterized by an increased risk of lymphoma in patients with prelymphomatous manifestations (i.e. myoepithelial sialadenitis or mixed cryoglobulinaemia). Serum B-lymphocyte stimulator (s-BLyS) levels in SS-related B-cell lymphoproliferative disorders were studied by integrating the results with the disease activity score and with molecular analyses of B-cell expansion in the salivary glands. Methods: Seventy-six primary SS patients (with or without lymphoma or prelymphomatous manifestations), 56 HCV-related cryoglobulinaemic vasculitis patients and 55 controls were studied. s-BLyS and molecular analyses of B-cell expansion in the salivary gland tissues were performed. Patients with SS and persistent parotid swelling underwent parotid biopsy. Results: S-BLyS differed between SS subgroups, higher levels being documented in patients with lymphoma or prelymphomatous manifestations vs SS without [1.85 (0.45-4.12) ng/ml vs 1.12 (0.56-1.98) ng/ml; P

Original languageEnglish
Article numberkes180
Pages (from-to)276-281
Number of pages6
JournalRheumatology
Volume52
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • B-cell activating factor
  • Blys
  • Lymphoma
  • S
  • Salivary glands

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

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