BM ageing: Implication for cell therapy with EPCs

Erica Rurali, Beatrice Bassetti, Gianluca Lorenzo Perrucci, Marco Zanobini, Cristina Malafronte, Felice Achilli, Elisa Gambini

Research output: Contribution to journalArticlepeer-review

Abstract

The bone marrow (BM) is a well-recognized source of stem/progenitor cells for cell therapy in cardiovascular diseases (CVDs). Preclinical and clinical studies suggest that endothelial progenitor cells (EPCs) contribute to reparative process of vascular endothelium and participate in angiogenesis. As for all organs and cells across the lifespan, BM and EPCs are negatively impacted by ageing due to microenvironment modifications and EPC progressive dysfunctions. The encouraging results in terms of neovascularization observed in young animals after EPC administration were mitigated in aged patients treated for ischemic CVDs. The limited efficacy of EPC-based therapy in clinical setting might be ascribed at least partly to ageing. In this review, we comprehensively discussed the age-related changes of BM and EPCs and their implication for cardiovascular cell-therapies. Finally, we examined alternative approaches under investigation to enhance EPC potency.

Original languageEnglish
JournalMechanisms of Ageing and Development
DOIs
Publication statusAccepted/In press - Dec 30 2015

Keywords

  • Ageing
  • Bone marrow
  • Cardiovascular disease
  • Cell therapy
  • EPC

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

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