BM ageing: Implication for cell therapy with EPCs

Erica Rurali, Beatrice Bassetti, Gianluca Lorenzo Perrucci, Marco Zanobini, Cristina Malafronte, Felice Achilli, Elisa Gambini

Research output: Contribution to journalArticle

Abstract

The bone marrow (BM) is a well-recognized source of stem/progenitor cells for cell therapy in cardiovascular diseases (CVDs). Preclinical and clinical studies suggest that endothelial progenitor cells (EPCs) contribute to reparative process of vascular endothelium and participate in angiogenesis. As for all organs and cells across the lifespan, BM and EPCs are negatively impacted by ageing due to microenvironment modifications and EPC progressive dysfunctions. The encouraging results in terms of neovascularization observed in young animals after EPC administration were mitigated in aged patients treated for ischemic CVDs. The limited efficacy of EPC-based therapy in clinical setting might be ascribed at least partly to ageing. In this review, we comprehensively discussed the age-related changes of BM and EPCs and their implication for cardiovascular cell-therapies. Finally, we examined alternative approaches under investigation to enhance EPC potency.

Original languageEnglish
Pages (from-to)4-13
Number of pages10
JournalMechanisms of Ageing and Development
Volume159
DOIs
Publication statusPublished - Oct 2016

Fingerprint

Cell- and Tissue-Based Therapy
Bone Marrow
Cardiovascular Diseases
Stem Cells
Vascular Endothelium
Endothelial Progenitor Cells

Keywords

  • Review
  • Journal Article

Cite this

BM ageing : Implication for cell therapy with EPCs. / Rurali, Erica; Bassetti, Beatrice; Perrucci, Gianluca Lorenzo; Zanobini, Marco; Malafronte, Cristina; Achilli, Felice; Gambini, Elisa.

In: Mechanisms of Ageing and Development, Vol. 159, 10.2016, p. 4-13.

Research output: Contribution to journalArticle

Rurali, Erica ; Bassetti, Beatrice ; Perrucci, Gianluca Lorenzo ; Zanobini, Marco ; Malafronte, Cristina ; Achilli, Felice ; Gambini, Elisa. / BM ageing : Implication for cell therapy with EPCs. In: Mechanisms of Ageing and Development. 2016 ; Vol. 159. pp. 4-13.
@article{8f81596575b14e84b3131c9a5f2c06e1,
title = "BM ageing: Implication for cell therapy with EPCs",
abstract = "The bone marrow (BM) is a well-recognized source of stem/progenitor cells for cell therapy in cardiovascular diseases (CVDs). Preclinical and clinical studies suggest that endothelial progenitor cells (EPCs) contribute to reparative process of vascular endothelium and participate in angiogenesis. As for all organs and cells across the lifespan, BM and EPCs are negatively impacted by ageing due to microenvironment modifications and EPC progressive dysfunctions. The encouraging results in terms of neovascularization observed in young animals after EPC administration were mitigated in aged patients treated for ischemic CVDs. The limited efficacy of EPC-based therapy in clinical setting might be ascribed at least partly to ageing. In this review, we comprehensively discussed the age-related changes of BM and EPCs and their implication for cardiovascular cell-therapies. Finally, we examined alternative approaches under investigation to enhance EPC potency.",
keywords = "Review, Journal Article",
author = "Erica Rurali and Beatrice Bassetti and Perrucci, {Gianluca Lorenzo} and Marco Zanobini and Cristina Malafronte and Felice Achilli and Elisa Gambini",
note = "Copyright {\circledC} 2016 Elsevier Ireland Ltd. All rights reserved.",
year = "2016",
month = "10",
doi = "10.1016/j.mad.2016.04.002",
language = "English",
volume = "159",
pages = "4--13",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - BM ageing

T2 - Implication for cell therapy with EPCs

AU - Rurali, Erica

AU - Bassetti, Beatrice

AU - Perrucci, Gianluca Lorenzo

AU - Zanobini, Marco

AU - Malafronte, Cristina

AU - Achilli, Felice

AU - Gambini, Elisa

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/10

Y1 - 2016/10

N2 - The bone marrow (BM) is a well-recognized source of stem/progenitor cells for cell therapy in cardiovascular diseases (CVDs). Preclinical and clinical studies suggest that endothelial progenitor cells (EPCs) contribute to reparative process of vascular endothelium and participate in angiogenesis. As for all organs and cells across the lifespan, BM and EPCs are negatively impacted by ageing due to microenvironment modifications and EPC progressive dysfunctions. The encouraging results in terms of neovascularization observed in young animals after EPC administration were mitigated in aged patients treated for ischemic CVDs. The limited efficacy of EPC-based therapy in clinical setting might be ascribed at least partly to ageing. In this review, we comprehensively discussed the age-related changes of BM and EPCs and their implication for cardiovascular cell-therapies. Finally, we examined alternative approaches under investigation to enhance EPC potency.

AB - The bone marrow (BM) is a well-recognized source of stem/progenitor cells for cell therapy in cardiovascular diseases (CVDs). Preclinical and clinical studies suggest that endothelial progenitor cells (EPCs) contribute to reparative process of vascular endothelium and participate in angiogenesis. As for all organs and cells across the lifespan, BM and EPCs are negatively impacted by ageing due to microenvironment modifications and EPC progressive dysfunctions. The encouraging results in terms of neovascularization observed in young animals after EPC administration were mitigated in aged patients treated for ischemic CVDs. The limited efficacy of EPC-based therapy in clinical setting might be ascribed at least partly to ageing. In this review, we comprehensively discussed the age-related changes of BM and EPCs and their implication for cardiovascular cell-therapies. Finally, we examined alternative approaches under investigation to enhance EPC potency.

KW - Review

KW - Journal Article

U2 - 10.1016/j.mad.2016.04.002

DO - 10.1016/j.mad.2016.04.002

M3 - Article

C2 - 27045606

VL - 159

SP - 4

EP - 13

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

ER -