BMJ open tobacco smoking and risk of endometriosis: A systematic review and meta-analysis

Francesca Bravi, Fabio Parazzini, Sonia Cipriani, Francesca Chiaffarino, Elena Ricci, Vito Chiantera, Paola Viganò, Carlo La Vecchia

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Objective: Since conflicting results have been published on the role of tobacco smoking on the risk of endometriosis, we provide an up-to-date summary quantification of this potential association. Design: We performed a PubMed/MEDLINE search of the relevant publications up to September 2014, considering studies on humans published in English. We searched the reference list of the identified papers to find other relevant publications. Case-control as well as cohort studies have been included reporting risk estimates on the association between tobacco smoking and endometriosis. 38 of the 1758 screened papers met the inclusion criteria. The selected studies included a total of 13 129 women diagnosed with endometriosis. Setting: Academic hospitals. Main outcome measure: Risk of endometriosis in tobacco smokers. Results: We obtained the summary estimates of the relative risk (RR) using the random effect model, and assessed the heterogeneity among studies using the X2 test and quantified it using the I2 statistic. As compared to never-smokers, the summary RR were 0.96 (95% CI 0.86 to 1.08) for ever smokers, 0.95 (95% CI 0.81 to 1.11) for former smokers, 0.92 (95% CI 0.82 to 1.04) for current smokers, 0.87 (95% CI 0.70 to 1.07) for moderate smokers and 0.93 (95% CI 0.69 to 1.26) for heavy smokers. Conclusions: The present meta-analysis provided no evidence for an association between tobacco smoking and the risk of endometriosis. The results were consistent considering ever, former, current, moderate and heavy smokers, and across type of endometriosis and study design.

Original languageEnglish
Article numbere006325
JournalBMJ Open
Volume4
DOIs
Publication statusPublished - 2014

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Endometriosis
Meta-Analysis
Smoking
Publications
PubMed
MEDLINE
Tobacco
Case-Control Studies
Cohort Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

BMJ open tobacco smoking and risk of endometriosis : A systematic review and meta-analysis. / Bravi, Francesca; Parazzini, Fabio; Cipriani, Sonia; Chiaffarino, Francesca; Ricci, Elena; Chiantera, Vito; Viganò, Paola; La Vecchia, Carlo.

In: BMJ Open, Vol. 4, e006325, 2014.

Research output: Contribution to journalReview article

Bravi, Francesca ; Parazzini, Fabio ; Cipriani, Sonia ; Chiaffarino, Francesca ; Ricci, Elena ; Chiantera, Vito ; Viganò, Paola ; La Vecchia, Carlo. / BMJ open tobacco smoking and risk of endometriosis : A systematic review and meta-analysis. In: BMJ Open. 2014 ; Vol. 4.
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abstract = "Objective: Since conflicting results have been published on the role of tobacco smoking on the risk of endometriosis, we provide an up-to-date summary quantification of this potential association. Design: We performed a PubMed/MEDLINE search of the relevant publications up to September 2014, considering studies on humans published in English. We searched the reference list of the identified papers to find other relevant publications. Case-control as well as cohort studies have been included reporting risk estimates on the association between tobacco smoking and endometriosis. 38 of the 1758 screened papers met the inclusion criteria. The selected studies included a total of 13 129 women diagnosed with endometriosis. Setting: Academic hospitals. Main outcome measure: Risk of endometriosis in tobacco smokers. Results: We obtained the summary estimates of the relative risk (RR) using the random effect model, and assessed the heterogeneity among studies using the X2 test and quantified it using the I2 statistic. As compared to never-smokers, the summary RR were 0.96 (95{\%} CI 0.86 to 1.08) for ever smokers, 0.95 (95{\%} CI 0.81 to 1.11) for former smokers, 0.92 (95{\%} CI 0.82 to 1.04) for current smokers, 0.87 (95{\%} CI 0.70 to 1.07) for moderate smokers and 0.93 (95{\%} CI 0.69 to 1.26) for heavy smokers. Conclusions: The present meta-analysis provided no evidence for an association between tobacco smoking and the risk of endometriosis. The results were consistent considering ever, former, current, moderate and heavy smokers, and across type of endometriosis and study design.",
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AU - Bravi, Francesca

AU - Parazzini, Fabio

AU - Cipriani, Sonia

AU - Chiaffarino, Francesca

AU - Ricci, Elena

AU - Chiantera, Vito

AU - Viganò, Paola

AU - La Vecchia, Carlo

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N2 - Objective: Since conflicting results have been published on the role of tobacco smoking on the risk of endometriosis, we provide an up-to-date summary quantification of this potential association. Design: We performed a PubMed/MEDLINE search of the relevant publications up to September 2014, considering studies on humans published in English. We searched the reference list of the identified papers to find other relevant publications. Case-control as well as cohort studies have been included reporting risk estimates on the association between tobacco smoking and endometriosis. 38 of the 1758 screened papers met the inclusion criteria. The selected studies included a total of 13 129 women diagnosed with endometriosis. Setting: Academic hospitals. Main outcome measure: Risk of endometriosis in tobacco smokers. Results: We obtained the summary estimates of the relative risk (RR) using the random effect model, and assessed the heterogeneity among studies using the X2 test and quantified it using the I2 statistic. As compared to never-smokers, the summary RR were 0.96 (95% CI 0.86 to 1.08) for ever smokers, 0.95 (95% CI 0.81 to 1.11) for former smokers, 0.92 (95% CI 0.82 to 1.04) for current smokers, 0.87 (95% CI 0.70 to 1.07) for moderate smokers and 0.93 (95% CI 0.69 to 1.26) for heavy smokers. Conclusions: The present meta-analysis provided no evidence for an association between tobacco smoking and the risk of endometriosis. The results were consistent considering ever, former, current, moderate and heavy smokers, and across type of endometriosis and study design.

AB - Objective: Since conflicting results have been published on the role of tobacco smoking on the risk of endometriosis, we provide an up-to-date summary quantification of this potential association. Design: We performed a PubMed/MEDLINE search of the relevant publications up to September 2014, considering studies on humans published in English. We searched the reference list of the identified papers to find other relevant publications. Case-control as well as cohort studies have been included reporting risk estimates on the association between tobacco smoking and endometriosis. 38 of the 1758 screened papers met the inclusion criteria. The selected studies included a total of 13 129 women diagnosed with endometriosis. Setting: Academic hospitals. Main outcome measure: Risk of endometriosis in tobacco smokers. Results: We obtained the summary estimates of the relative risk (RR) using the random effect model, and assessed the heterogeneity among studies using the X2 test and quantified it using the I2 statistic. As compared to never-smokers, the summary RR were 0.96 (95% CI 0.86 to 1.08) for ever smokers, 0.95 (95% CI 0.81 to 1.11) for former smokers, 0.92 (95% CI 0.82 to 1.04) for current smokers, 0.87 (95% CI 0.70 to 1.07) for moderate smokers and 0.93 (95% CI 0.69 to 1.26) for heavy smokers. Conclusions: The present meta-analysis provided no evidence for an association between tobacco smoking and the risk of endometriosis. The results were consistent considering ever, former, current, moderate and heavy smokers, and across type of endometriosis and study design.

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