Abstract
To evaluate and compare cardiovascular adaptation of 36 preterm and 34 fullterm newborns, we analyzed BNP concentration and echocardiographic parameters at day 3 of life and at day 28 (± 2). On day 3 BNP concentrations (pg/ml) resulted higher in PDA preterm group (n= 11; 125, IQR 56.1-301) than preterm without PDA (n= 25; 25.5 IQR 10.9-49; p<0.001) than fullterms (n= 34; 55.1 IQR 23.6-82.7; p= 0.013). No difference resulted in all groups at 28. days (respectively: 12.7 IQR 4.9-23.8; 15.6 IQR 10-22; 8.9 IQR 5.6-20.6). Because of the newborns' growth, all echocardiographic parameters increased with linear relationship with body weight. On day 3 BNP concentration and echocardiographic parameters were not correlated besides LA/AO in preterms with PDA (p= 0.0015). On day 28, BNP was significantly correlated with mVTI (p= 0.019), M (p= 0.007) and LA (p= 0.005) in fullterms and only with LA (p= 0.007) in preterms.In conclusion, BNP concentrations and echocardiographic measures confirm that preterm, and fullterm newborns conduct themselves in a similar manner during the transition from foetal to post-natal circulation, reaching low levels at a month of life. The presence of PDA during first days of life has no significant impact in this adaptation. LA is the echocardiographic parameter mostly related to BNP concentration in the newborns.
| Original language | English |
|---|---|
| Pages (from-to) | 295-298 |
| Number of pages | 4 |
| Journal | Early Human Development |
| Volume | 86 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2010 |
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Keywords
- BNP
- Echocardiography
- Newborns
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynaecology
- Medicine(all)
Cite this
BNP concentrations and cardiovascular adaptation in preterm and fullterm newborn infants. / Mannarino, Savina; Garofoli, Francesca; Mongini, Elisa; Cerbo, Rosa Maria; Codazzi, Alessia Claudia; Tzialla, Chryssoula; Mazzucchelli, Iolanda; Perotti, Gianfranco; Tinelli, Carmine; De Silvestri, Annalisa; Manzoni, Paolo; Stronati, Mauro.
In: Early Human Development, Vol. 86, No. 5, 05.2010, p. 295-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - BNP concentrations and cardiovascular adaptation in preterm and fullterm newborn infants
AU - Mannarino, Savina
AU - Garofoli, Francesca
AU - Mongini, Elisa
AU - Cerbo, Rosa Maria
AU - Codazzi, Alessia Claudia
AU - Tzialla, Chryssoula
AU - Mazzucchelli, Iolanda
AU - Perotti, Gianfranco
AU - Tinelli, Carmine
AU - De Silvestri, Annalisa
AU - Manzoni, Paolo
AU - Stronati, Mauro
PY - 2010/5
Y1 - 2010/5
N2 - To evaluate and compare cardiovascular adaptation of 36 preterm and 34 fullterm newborns, we analyzed BNP concentration and echocardiographic parameters at day 3 of life and at day 28 (± 2). On day 3 BNP concentrations (pg/ml) resulted higher in PDA preterm group (n= 11; 125, IQR 56.1-301) than preterm without PDA (n= 25; 25.5 IQR 10.9-49; p<0.001) than fullterms (n= 34; 55.1 IQR 23.6-82.7; p= 0.013). No difference resulted in all groups at 28. days (respectively: 12.7 IQR 4.9-23.8; 15.6 IQR 10-22; 8.9 IQR 5.6-20.6). Because of the newborns' growth, all echocardiographic parameters increased with linear relationship with body weight. On day 3 BNP concentration and echocardiographic parameters were not correlated besides LA/AO in preterms with PDA (p= 0.0015). On day 28, BNP was significantly correlated with mVTI (p= 0.019), M (p= 0.007) and LA (p= 0.005) in fullterms and only with LA (p= 0.007) in preterms.In conclusion, BNP concentrations and echocardiographic measures confirm that preterm, and fullterm newborns conduct themselves in a similar manner during the transition from foetal to post-natal circulation, reaching low levels at a month of life. The presence of PDA during first days of life has no significant impact in this adaptation. LA is the echocardiographic parameter mostly related to BNP concentration in the newborns.
AB - To evaluate and compare cardiovascular adaptation of 36 preterm and 34 fullterm newborns, we analyzed BNP concentration and echocardiographic parameters at day 3 of life and at day 28 (± 2). On day 3 BNP concentrations (pg/ml) resulted higher in PDA preterm group (n= 11; 125, IQR 56.1-301) than preterm without PDA (n= 25; 25.5 IQR 10.9-49; p<0.001) than fullterms (n= 34; 55.1 IQR 23.6-82.7; p= 0.013). No difference resulted in all groups at 28. days (respectively: 12.7 IQR 4.9-23.8; 15.6 IQR 10-22; 8.9 IQR 5.6-20.6). Because of the newborns' growth, all echocardiographic parameters increased with linear relationship with body weight. On day 3 BNP concentration and echocardiographic parameters were not correlated besides LA/AO in preterms with PDA (p= 0.0015). On day 28, BNP was significantly correlated with mVTI (p= 0.019), M (p= 0.007) and LA (p= 0.005) in fullterms and only with LA (p= 0.007) in preterms.In conclusion, BNP concentrations and echocardiographic measures confirm that preterm, and fullterm newborns conduct themselves in a similar manner during the transition from foetal to post-natal circulation, reaching low levels at a month of life. The presence of PDA during first days of life has no significant impact in this adaptation. LA is the echocardiographic parameter mostly related to BNP concentration in the newborns.
KW - BNP
KW - Echocardiography
KW - Newborns
UR - http://www.scopus.com/inward/record.url?scp=77954032449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954032449&partnerID=8YFLogxK
U2 - 10.1016/j.earlhumdev.2010.04.003
DO - 10.1016/j.earlhumdev.2010.04.003
M3 - Article
C2 - 20488634
AN - SCOPUS:77954032449
VL - 86
SP - 295
EP - 298
JO - Early Human Development
JF - Early Human Development
SN - 0378-3782
IS - 5
ER -