BNP concentrations and cardiovascular adaptation in preterm and fullterm newborn infants

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Abstract

To evaluate and compare cardiovascular adaptation of 36 preterm and 34 fullterm newborns, we analyzed BNP concentration and echocardiographic parameters at day 3 of life and at day 28 (± 2). On day 3 BNP concentrations (pg/ml) resulted higher in PDA preterm group (n= 11; 125, IQR 56.1-301) than preterm without PDA (n= 25; 25.5 IQR 10.9-49; p<0.001) than fullterms (n= 34; 55.1 IQR 23.6-82.7; p= 0.013). No difference resulted in all groups at 28. days (respectively: 12.7 IQR 4.9-23.8; 15.6 IQR 10-22; 8.9 IQR 5.6-20.6). Because of the newborns' growth, all echocardiographic parameters increased with linear relationship with body weight. On day 3 BNP concentration and echocardiographic parameters were not correlated besides LA/AO in preterms with PDA (p= 0.0015). On day 28, BNP was significantly correlated with mVTI (p= 0.019), M (p= 0.007) and LA (p= 0.005) in fullterms and only with LA (p= 0.007) in preterms.In conclusion, BNP concentrations and echocardiographic measures confirm that preterm, and fullterm newborns conduct themselves in a similar manner during the transition from foetal to post-natal circulation, reaching low levels at a month of life. The presence of PDA during first days of life has no significant impact in this adaptation. LA is the echocardiographic parameter mostly related to BNP concentration in the newborns.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalEarly Human Development
Volume86
Issue number5
DOIs
Publication statusPublished - May 2010

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Newborn Infant
Body Weight
Growth

Keywords

  • BNP
  • Echocardiography
  • Newborns

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology
  • Medicine(all)

Cite this

@article{213a8c1ebd6d42c4b88e392000065c80,
title = "BNP concentrations and cardiovascular adaptation in preterm and fullterm newborn infants",
abstract = "To evaluate and compare cardiovascular adaptation of 36 preterm and 34 fullterm newborns, we analyzed BNP concentration and echocardiographic parameters at day 3 of life and at day 28 (± 2). On day 3 BNP concentrations (pg/ml) resulted higher in PDA preterm group (n= 11; 125, IQR 56.1-301) than preterm without PDA (n= 25; 25.5 IQR 10.9-49; p<0.001) than fullterms (n= 34; 55.1 IQR 23.6-82.7; p= 0.013). No difference resulted in all groups at 28. days (respectively: 12.7 IQR 4.9-23.8; 15.6 IQR 10-22; 8.9 IQR 5.6-20.6). Because of the newborns' growth, all echocardiographic parameters increased with linear relationship with body weight. On day 3 BNP concentration and echocardiographic parameters were not correlated besides LA/AO in preterms with PDA (p= 0.0015). On day 28, BNP was significantly correlated with mVTI (p= 0.019), M (p= 0.007) and LA (p= 0.005) in fullterms and only with LA (p= 0.007) in preterms.In conclusion, BNP concentrations and echocardiographic measures confirm that preterm, and fullterm newborns conduct themselves in a similar manner during the transition from foetal to post-natal circulation, reaching low levels at a month of life. The presence of PDA during first days of life has no significant impact in this adaptation. LA is the echocardiographic parameter mostly related to BNP concentration in the newborns.",
keywords = "BNP, Echocardiography, Newborns",
author = "Savina Mannarino and Francesca Garofoli and Elisa Mongini and Cerbo, {Rosa Maria} and Codazzi, {Alessia Claudia} and Chryssoula Tzialla and Iolanda Mazzucchelli and Gianfranco Perotti and Carmine Tinelli and {De Silvestri}, Annalisa and Paolo Manzoni and Mauro Stronati",
year = "2010",
month = "5",
doi = "10.1016/j.earlhumdev.2010.04.003",
language = "English",
volume = "86",
pages = "295--298",
journal = "Early Human Development",
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TY - JOUR

T1 - BNP concentrations and cardiovascular adaptation in preterm and fullterm newborn infants

AU - Mannarino, Savina

AU - Garofoli, Francesca

AU - Mongini, Elisa

AU - Cerbo, Rosa Maria

AU - Codazzi, Alessia Claudia

AU - Tzialla, Chryssoula

AU - Mazzucchelli, Iolanda

AU - Perotti, Gianfranco

AU - Tinelli, Carmine

AU - De Silvestri, Annalisa

AU - Manzoni, Paolo

AU - Stronati, Mauro

PY - 2010/5

Y1 - 2010/5

N2 - To evaluate and compare cardiovascular adaptation of 36 preterm and 34 fullterm newborns, we analyzed BNP concentration and echocardiographic parameters at day 3 of life and at day 28 (± 2). On day 3 BNP concentrations (pg/ml) resulted higher in PDA preterm group (n= 11; 125, IQR 56.1-301) than preterm without PDA (n= 25; 25.5 IQR 10.9-49; p<0.001) than fullterms (n= 34; 55.1 IQR 23.6-82.7; p= 0.013). No difference resulted in all groups at 28. days (respectively: 12.7 IQR 4.9-23.8; 15.6 IQR 10-22; 8.9 IQR 5.6-20.6). Because of the newborns' growth, all echocardiographic parameters increased with linear relationship with body weight. On day 3 BNP concentration and echocardiographic parameters were not correlated besides LA/AO in preterms with PDA (p= 0.0015). On day 28, BNP was significantly correlated with mVTI (p= 0.019), M (p= 0.007) and LA (p= 0.005) in fullterms and only with LA (p= 0.007) in preterms.In conclusion, BNP concentrations and echocardiographic measures confirm that preterm, and fullterm newborns conduct themselves in a similar manner during the transition from foetal to post-natal circulation, reaching low levels at a month of life. The presence of PDA during first days of life has no significant impact in this adaptation. LA is the echocardiographic parameter mostly related to BNP concentration in the newborns.

AB - To evaluate and compare cardiovascular adaptation of 36 preterm and 34 fullterm newborns, we analyzed BNP concentration and echocardiographic parameters at day 3 of life and at day 28 (± 2). On day 3 BNP concentrations (pg/ml) resulted higher in PDA preterm group (n= 11; 125, IQR 56.1-301) than preterm without PDA (n= 25; 25.5 IQR 10.9-49; p<0.001) than fullterms (n= 34; 55.1 IQR 23.6-82.7; p= 0.013). No difference resulted in all groups at 28. days (respectively: 12.7 IQR 4.9-23.8; 15.6 IQR 10-22; 8.9 IQR 5.6-20.6). Because of the newborns' growth, all echocardiographic parameters increased with linear relationship with body weight. On day 3 BNP concentration and echocardiographic parameters were not correlated besides LA/AO in preterms with PDA (p= 0.0015). On day 28, BNP was significantly correlated with mVTI (p= 0.019), M (p= 0.007) and LA (p= 0.005) in fullterms and only with LA (p= 0.007) in preterms.In conclusion, BNP concentrations and echocardiographic measures confirm that preterm, and fullterm newborns conduct themselves in a similar manner during the transition from foetal to post-natal circulation, reaching low levels at a month of life. The presence of PDA during first days of life has no significant impact in this adaptation. LA is the echocardiographic parameter mostly related to BNP concentration in the newborns.

KW - BNP

KW - Echocardiography

KW - Newborns

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U2 - 10.1016/j.earlhumdev.2010.04.003

DO - 10.1016/j.earlhumdev.2010.04.003

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VL - 86

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EP - 298

JO - Early Human Development

JF - Early Human Development

SN - 0378-3782

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