Bocavirus infection in otherwise healthy children with respiratory disease

Nicola Principi; Antonio Piralla; Alberto Zampiero; Sonia Bianchini; Giulia Umbrello; Alessia Scala; Samantha Bosis; Emilio Fossali; Fausto Baldanti; Susanna Esposito

doi:10.1371/journal.pone.0135640

Bocavirus infection in otherwise healthy children with respiratory disease

Nicola Principi, Antonio Piralla, Alberto Zampiero, Sonia Bianchini, Giulia Umbrello, Alessia Scala, Samantha Bosis, Emilio Fossali, Fausto Baldanti, Susanna Esposito

Research output: Contribution to journal › Article

Abstract

To evaluate the role of human bocavirus (hBoV) as a causative agent of respiratory disease, the importance of the viral load in respiratory disease type and severity and the pathogenicity of the different hBoV species, we studied all hBoV-positive nasopharyngeal samples collected from children who attended an emergency room for a respiratory tract infection during three winters (2009-2010, 2011-2012, and 2013-2014). Human bocavirus was detected using the respiratory virus panel fast assay and real-time PCR. Of the 1,823 nasopharyngeal samples, 104 (5.7%) were positive for hBoV; a similar prevalence was observed in all three periods studied. Among hBoV-infected children, 53.8% were between 1-2 years old, and hBoV was detected alone in 57/104 (54.8%) cases. All of the detected hBoV strains belonged to genotype 1. The median hBoV load was significantly higher in samples containing strains with both the N546H and T590S mutations compared to other samples (p

Original language	English
Article number	e0135640
Journal	PLoS One
Volume	10
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0135640
Publication status	Published - Aug 12 2015

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Principi, N., Piralla, A., Zampiero, A., Bianchini, S., Umbrello, G., Scala, A., Bosis, S., Fossali, E., Baldanti, F., & Esposito, S. (2015). Bocavirus infection in otherwise healthy children with respiratory disease. PLoS One, 10(8), [e0135640]. https://doi.org/10.1371/journal.pone.0135640

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AU - Principi, Nicola

AU - Piralla, Antonio

AU - Zampiero, Alberto

AU - Bianchini, Sonia

AU - Umbrello, Giulia

AU - Scala, Alessia

AU - Bosis, Samantha

AU - Fossali, Emilio

AU - Baldanti, Fausto

AU - Esposito, Susanna

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