Bocavirus infection in otherwise healthy children with respiratory disease

Nicola Principi, Antonio Piralla, Alberto Zampiero, Sonia Bianchini, Giulia Umbrello, Alessia Scala, Samantha Bosis, Emilio Fossali, Fausto Baldanti, Susanna Esposito

Research output: Contribution to journalArticlepeer-review


To evaluate the role of human bocavirus (hBoV) as a causative agent of respiratory disease, the importance of the viral load in respiratory disease type and severity and the pathogenicity of the different hBoV species, we studied all hBoV-positive nasopharyngeal samples collected from children who attended an emergency room for a respiratory tract infection during three winters (2009-2010, 2011-2012, and 2013-2014). Human bocavirus was detected using the respiratory virus panel fast assay and real-time PCR. Of the 1,823 nasopharyngeal samples, 104 (5.7%) were positive for hBoV; a similar prevalence was observed in all three periods studied. Among hBoV-infected children, 53.8% were between 1-2 years old, and hBoV was detected alone in 57/104 (54.8%) cases. All of the detected hBoV strains belonged to genotype 1. The median hBoV load was significantly higher in samples containing strains with both the N546H and T590S mutations compared to other samples (p

Original languageEnglish
Article numbere0135640
JournalPLoS One
Issue number8
Publication statusPublished - Aug 12 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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