Body mass, chronic heart failure, surgery and survival

Andrew L. Clark, Stefan D. Anker

Research output: Contribution to journalArticlepeer-review


Cardiac cachexia, associated with excessive activation of the sympathetic nervous system together with immune activation, is an important prognostic indicator in heart failure. Anecdotally, the prevalence of cardiac cachexia appears to be falling, perhaps due to the increased use of beta-blockers. However, chronic heart failure is so common that many patients continue to lose weight and continue to deteriorate to a point where transplantation or mechanical support is considered. The origin of cachexia remains elusive and further research is needed to explore the relation between weight, sympathetic activation, and the response to cardiac surgery or transplantation.

Original languageEnglish
Pages (from-to)261-264
Number of pages4
JournalJournal of Heart and Lung Transplantation
Issue number3
Publication statusPublished - Mar 2010


  • cardiac cachexia
  • heart failure
  • mechanical support
  • outcome

ASJC Scopus subject areas

  • Transplantation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery


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