Body mass index and preinfarction angina in elderly patients with acute myocardial infarction

Pasquale Abete, Francesco Cacciatore, Nicola Ferrara, Claudio Calabrese, Domenico De Santis, Gianluca Testa, Gianluigi Galizia, Stefania Del Vecchio, Dario Leosco, Mario Condorelli, Claudio Napoli, Franco Rengo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Preinfarction angina, a clinical equivalent of ischemic preconditioning, seems to protect against in-hospital death, cardiogenic shock, and the combined endpoints in adult but not in elderly patients with acute myocardial infarction. Experimental evidence indicates that caloric restriction may restore ischemic preconditioning in aged animals. Objective: The objective was to verify whether body mass index (BMI) influences the cardioprotective effect of preinfarction angina in the elderly. Design: We retrospectively studied 820 patients aged ≥ 65 y with acute myocardial infarction by evaluating BMI and major (death and cardiogenic shock) and minor in-hospital outcomes. Results: In-hospital death, cardiogenic shock, and the combined endpoints were not significantly different between elderly patients with and without preinfarction angina. Interestingly, in-hospital death, cardiogenic shock, and the combined endpoints were significantly fewer in elderly patients with than without preinfarction angina in the subset of patients with the lowest BMI (P <0.01,

Original languageEnglish
Pages (from-to)796-801
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume78
Issue number4
Publication statusPublished - Oct 2003

Keywords

  • Aging
  • Body mass index
  • Elderly
  • Mortality
  • Preinfarction angina

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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