Body Mass Index and Serum Proteomic Profile in Breast Cancer and Healthy Women: A Prospective Study

Vito Michele Garrisi, Antonio Tufaro, Paolo Trerotoli, Italia Bongarzone, Michele Quaranta, Vincenzo Ventrella, Stefania Tommasi, Gianluigi Giannelli, Angelo Paradiso

Research output: Contribution to journalArticlepeer-review

Abstract

Epidemiological studies suggest a possible association between BMI, diagnosis and clinical-pathological breast cancer characteristics but biological bases for this relationship still remain to be ascertained. Several biological mechanisms play a role in the genesis and progression of breast cancer. This study aimed to investigate relationships between BMI and breast cancer diagnosis/progression in a Southern Italian population and to try to interpret results according to the serum proteomic profile of healthy and breast cancer patients. BMI, presence or absence of breast cancer and its clinical-pathological characteristics were analyzed in a series of 300 breast cancer women and compared with those of 300 healthy women prospectively. To investigate whether obesity is associated with alterations in serum protein profile, SELDI-ToF approach was applied. Alcohol consumption (22.7% vs 11.3%; p = 30 respect to normal weight: OR = 2.49, 95% CI 1.25-4.99, p = 0.0098) and a higher probability of having positive axillary lymph node (OR = 3.67, CI 95% 2.16-6.23, p

Original languageEnglish
Article numbere49631
JournalPLoS One
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 30 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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