Abstract
Epidemiological studies suggest a possible association between BMI, diagnosis and clinical-pathological breast cancer characteristics but biological bases for this relationship still remain to be ascertained. Several biological mechanisms play a role in the genesis and progression of breast cancer. This study aimed to investigate relationships between BMI and breast cancer diagnosis/progression in a Southern Italian population and to try to interpret results according to the serum proteomic profile of healthy and breast cancer patients. BMI, presence or absence of breast cancer and its clinical-pathological characteristics were analyzed in a series of 300 breast cancer women and compared with those of 300 healthy women prospectively. To investigate whether obesity is associated with alterations in serum protein profile, SELDI-ToF approach was applied. Alcohol consumption (22.7% vs 11.3%; p = 30 respect to normal weight: OR = 2.49, 95% CI 1.25-4.99, p = 0.0098) and a higher probability of having positive axillary lymph node (OR = 3.67, CI 95% 2.16-6.23, p
| Original language | English |
|---|---|
| Article number | e49631 |
| Journal | PLoS One |
| Volume | 7 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 30 2012 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Body Mass Index and Serum Proteomic Profile in Breast Cancer and Healthy Women : A Prospective Study. / Garrisi, Vito Michele; Tufaro, Antonio; Trerotoli, Paolo; Bongarzone, Italia; Quaranta, Michele; Ventrella, Vincenzo; Tommasi, Stefania; Giannelli, Gianluigi; Paradiso, Angelo.
In: PLoS One, Vol. 7, No. 11, e49631, 30.11.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Body Mass Index and Serum Proteomic Profile in Breast Cancer and Healthy Women
T2 - A Prospective Study
AU - Garrisi, Vito Michele
AU - Tufaro, Antonio
AU - Trerotoli, Paolo
AU - Bongarzone, Italia
AU - Quaranta, Michele
AU - Ventrella, Vincenzo
AU - Tommasi, Stefania
AU - Giannelli, Gianluigi
AU - Paradiso, Angelo
PY - 2012/11/30
Y1 - 2012/11/30
N2 - Epidemiological studies suggest a possible association between BMI, diagnosis and clinical-pathological breast cancer characteristics but biological bases for this relationship still remain to be ascertained. Several biological mechanisms play a role in the genesis and progression of breast cancer. This study aimed to investigate relationships between BMI and breast cancer diagnosis/progression in a Southern Italian population and to try to interpret results according to the serum proteomic profile of healthy and breast cancer patients. BMI, presence or absence of breast cancer and its clinical-pathological characteristics were analyzed in a series of 300 breast cancer women and compared with those of 300 healthy women prospectively. To investigate whether obesity is associated with alterations in serum protein profile, SELDI-ToF approach was applied. Alcohol consumption (22.7% vs 11.3%; p = 30 respect to normal weight: OR = 2.49, 95% CI 1.25-4.99, p = 0.0098) and a higher probability of having positive axillary lymph node (OR = 3.67, CI 95% 2.16-6.23, p
AB - Epidemiological studies suggest a possible association between BMI, diagnosis and clinical-pathological breast cancer characteristics but biological bases for this relationship still remain to be ascertained. Several biological mechanisms play a role in the genesis and progression of breast cancer. This study aimed to investigate relationships between BMI and breast cancer diagnosis/progression in a Southern Italian population and to try to interpret results according to the serum proteomic profile of healthy and breast cancer patients. BMI, presence or absence of breast cancer and its clinical-pathological characteristics were analyzed in a series of 300 breast cancer women and compared with those of 300 healthy women prospectively. To investigate whether obesity is associated with alterations in serum protein profile, SELDI-ToF approach was applied. Alcohol consumption (22.7% vs 11.3%; p = 30 respect to normal weight: OR = 2.49, 95% CI 1.25-4.99, p = 0.0098) and a higher probability of having positive axillary lymph node (OR = 3.67, CI 95% 2.16-6.23, p
UR - http://www.scopus.com/inward/record.url?scp=84870697242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870697242&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0049631
DO - 10.1371/journal.pone.0049631
M3 - Article
C2 - 23226214
AN - SCOPUS:84870697242
VL - 7
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 11
M1 - e49631
ER -