TY - JOUR
T1 - Body mass index, nocturnal fall in blood pressure and organ damage in untreated essential hypertensive patients
AU - Cuspidi, Cesare
AU - Meani, Stefano
AU - Valerio, Cristiana
AU - Negri, Francesca
AU - Sala, Carla
AU - Maisaidi, Meilikemu
AU - Giudici, Valentina
AU - Zanchetti, Alberto
AU - Mancia, Giuseppe
PY - 2008/12
Y1 - 2008/12
N2 - Aim We sought to investigate the relationship between body mass index (BMI) and parameters derived from 48-h ambulatory blood pressure monitoring (ABPM) as well as organ damage in human hypertension. Methods A total of 658 consecutive outpatients with grade 1 and 2 hypertension, never treated with antihypertensive medications underwent the following procedures: (i) routine examination, (ii) 24-h urine collection for microalbuminuria, (iii) ABPM over two 24-h periods within 4 weeks, (iv) echocardiography and (v) carotid ultrasonography. Each patient was classified as lean (BMK25kg/m2) or overweight/obese (≥ 25kg/m2) and according to the consistency of the dipping or nondipping status in the first and second ABPM period, as dipper (DD), nondipper and variable dipper. Results Mean 48-h, daytime and nighttime systolic BP or diastolic BP were superimposable in the lean (n = 314) and overweight (n=344) group. Overweight patients had a reduced nocturnal BP drop compared with their lean counterparts; the prevalence of DD pattern, indeed, was 15% lower in the overweight group as a whole, with a 17% difference in men and 13% in women. The prevalence of left ventricular hypertrophy was higher in overweight than in lean patients (31.8 vs. 15.9% in men and 48.7 vs. 15.6% in women, P
AB - Aim We sought to investigate the relationship between body mass index (BMI) and parameters derived from 48-h ambulatory blood pressure monitoring (ABPM) as well as organ damage in human hypertension. Methods A total of 658 consecutive outpatients with grade 1 and 2 hypertension, never treated with antihypertensive medications underwent the following procedures: (i) routine examination, (ii) 24-h urine collection for microalbuminuria, (iii) ABPM over two 24-h periods within 4 weeks, (iv) echocardiography and (v) carotid ultrasonography. Each patient was classified as lean (BMK25kg/m2) or overweight/obese (≥ 25kg/m2) and according to the consistency of the dipping or nondipping status in the first and second ABPM period, as dipper (DD), nondipper and variable dipper. Results Mean 48-h, daytime and nighttime systolic BP or diastolic BP were superimposable in the lean (n = 314) and overweight (n=344) group. Overweight patients had a reduced nocturnal BP drop compared with their lean counterparts; the prevalence of DD pattern, indeed, was 15% lower in the overweight group as a whole, with a 17% difference in men and 13% in women. The prevalence of left ventricular hypertrophy was higher in overweight than in lean patients (31.8 vs. 15.9% in men and 48.7 vs. 15.6% in women, P
KW - Ambulatory blood pressure
KW - Body mass index
KW - Organ damage
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U2 - 10.1097/MBP.0b013e32830d4bf8
DO - 10.1097/MBP.0b013e32830d4bf8
M3 - Article
C2 - 19020422
AN - SCOPUS:57149145464
VL - 13
SP - 318
EP - 324
JO - Blood Pressure Monitoring
JF - Blood Pressure Monitoring
SN - 1359-5237
IS - 6
ER -