Body mass index, nocturnal fall in blood pressure and organ damage in untreated essential hypertensive patients

Cesare Cuspidi, Stefano Meani, Cristiana Valerio, Francesca Negri, Carla Sala, Meilikemu Maisaidi, Valentina Giudici, Alberto Zanchetti, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


Aim We sought to investigate the relationship between body mass index (BMI) and parameters derived from 48-h ambulatory blood pressure monitoring (ABPM) as well as organ damage in human hypertension. Methods A total of 658 consecutive outpatients with grade 1 and 2 hypertension, never treated with antihypertensive medications underwent the following procedures: (i) routine examination, (ii) 24-h urine collection for microalbuminuria, (iii) ABPM over two 24-h periods within 4 weeks, (iv) echocardiography and (v) carotid ultrasonography. Each patient was classified as lean (BMK25kg/m2) or overweight/obese (≥ 25kg/m2) and according to the consistency of the dipping or nondipping status in the first and second ABPM period, as dipper (DD), nondipper and variable dipper. Results Mean 48-h, daytime and nighttime systolic BP or diastolic BP were superimposable in the lean (n = 314) and overweight (n=344) group. Overweight patients had a reduced nocturnal BP drop compared with their lean counterparts; the prevalence of DD pattern, indeed, was 15% lower in the overweight group as a whole, with a 17% difference in men and 13% in women. The prevalence of left ventricular hypertrophy was higher in overweight than in lean patients (31.8 vs. 15.9% in men and 48.7 vs. 15.6% in women, P

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalBlood Pressure Monitoring
Issue number6
Publication statusPublished - Dec 2008


  • Ambulatory blood pressure
  • Body mass index
  • Organ damage

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Advanced and Specialised Nursing
  • Assessment and Diagnosis


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