Body mass index reduction improves the baseline procoagulant imbalance of obese subjects

Armando Tripodi, Massimo Primignani, Sara Badiali, Fausto de Ruberto, Paola Granelli, Giulia Tosetti, Marigrazia Clerici, Lidia Padovan, Veena Chantarangkul, Erica Scalambrino, Flora Peyvandi

Research output: Contribution to journalArticle

Abstract

Obesity is a risk factor for cardiovascular diseases. The latter being dependent (at least in part) on plasma procoagulant imbalance (i.e., hypercoagulability). Information on hypercoagulability associated with obesity is scanty and mainly based on global traditional coagulation tests or on the measurement of individual components of coagulation (i.e., pro- and anticoagulants). Plasma from 33 obese subjects was investigated soon before endoscopic balloon placement and after removal (6 months later) by thrombin-generation procedures that are thought to represent much better than any other in vitro test the coagulation process occurring in vivo. We found that obese subjects possess a state of hypercoagulability as demonstrated by the modification of the main parameters of thrombin-generation. In particular, the median value (min–max) of the endogenous thrombin potential (ETP) of obese subjects at baseline was higher than that of controls [1968 (1335–2533) vs. 1710 (1010–2119), p < 0.001]. Endoscopic balloon placement achieved a BMI reduction from 38.9 (31.7–62.3) to 31.6 (21.9–53.3), p < 0.001 and a parallel reduction of thrombin-generation as demonstrated by the following findings. The ETP measured soon after balloon removal was significantly smaller than that measured at baseline [1783 (1224–2642) vs. 1968 (1335–2533), p < 0.01]. The other parameters of thrombin-generation, including lag-time, peak-thrombin, time-to-reach the peak and velocity index showed a pattern consistent with the ETP, both at baseline and soon after balloon removal. Endoscopic balloon placement achieves concomitant reduction of BMI and thrombin-generation in subjects with obesity.

Original languageEnglish
Pages (from-to)52-60
Number of pages9
JournalJournal of Thrombosis and Thrombolysis
Volume48
Issue number1
DOIs
Publication statusPublished - Jul 15 2019

Fingerprint

Thrombin
Body Mass Index
Thrombophilia
Obesity
Thrombin Time
Anticoagulants
Cardiovascular Diseases

Keywords

  • Cardiovascular diseases
  • Endogenous thrombin potential
  • Endoscopic balloon therapy
  • Hypercoagulability
  • Thrombin generation

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Body mass index reduction improves the baseline procoagulant imbalance of obese subjects. / Tripodi, Armando; Primignani, Massimo; Badiali, Sara; de Ruberto, Fausto; Granelli, Paola; Tosetti, Giulia; Clerici, Marigrazia; Padovan, Lidia; Chantarangkul, Veena; Scalambrino, Erica; Peyvandi, Flora.

In: Journal of Thrombosis and Thrombolysis, Vol. 48, No. 1, 15.07.2019, p. 52-60.

Research output: Contribution to journalArticle

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