Body size and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Tobias Pischon, Petra H. Lahmann, Heiner Boeing, Christine Friedenreich, Teresa Norat, Anne Tjønneland, Jytte Halkjaer, Kim Overvad, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Gregory Guernec, Manuela M. Bergmann, Jakob Linseisen, Nikolaus Becker, Antonia Trichopoulou, Dimitrios Trichopoulos, Sabina Sieri, Domenico Palli, Rosario Tumino, Paolo VineisSalvatore Panico, Petra H M Peeters, H. Bas Bueno-de-Mesquita, Hendriek C. Boshuizen, Bethany Van Guelpen, Richard Palmqvist, Göran Berglund, Carlos Alberto Gonzalez, Miren Dorronsoro, Aurelio Barricarte, Carmen Navarro, Carmen Martinez, J. Ramón Quirós, Andrew Roddam, Naomi Allen, Sheila Bingham, Kay Tee Khaw, Pietro Ferrari, Rudolf Kaaks, Nadia Slimani, Elio Riboli

Research output: Contribution to journalArticle

Abstract

Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the association between anthropometric measures and risks of colon and rectal cancer among 368 277 men and women who were free of cancer at baseline from nine countries of the European Prospective Investigation Into Cancer and Nutrition. All statistical tests were two-sided. Results: During 6.1 years of follow-up, we identified 984 and 586 patients with colon and rectal cancer, respectively. Body weight and BMI were statistically significantly associated with colon cancer risk in men (highest versus lowest quintile of BMI, relative risk [RR] = 1.55, 95% confidence interval [CI] = 1.12 to 2.15; P trend =.006) but not in women. In contrast, comparisons of the highest to the lowest quintile showed that several anthropometric measures, including waist circumference (men, RR = 1.39, 95% CI = 1.01 to 1.93; P trend = .001; women, RR = 1.48, 95% CI = 1.08 to 2.03; P trend = .008), waist-to-hip ratio (WHR; men, RR = 1.51, 95% CI = 1.06 to 2.15; P trend = .006; women, RR = 1.52, 95% CI = 1.12 to 2.05; P trend = .002), and height (men, RR = 1.40, 95% CI = 0.99 to 1.98; P trend = .04; women, RR = 1.79, 95% CI = 1.30 to 2.46; P trend

Original languageEnglish
Pages (from-to)920-931
Number of pages12
JournalJournal of the National Cancer Institute
Volume98
Issue number13
DOIs
Publication statusPublished - Jul 5 2006

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Body Size
Rectal Neoplasms
Colonic Neoplasms
Confidence Intervals
Neoplasms
Body Mass Index
Body Weight
Sex Distribution
Waist-Hip Ratio
Hormone Replacement Therapy
Waist Circumference
Proportional Hazards Models
Fats

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pischon, T., Lahmann, P. H., Boeing, H., Friedenreich, C., Norat, T., Tjønneland, A., ... Riboli, E. (2006). Body size and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Journal of the National Cancer Institute, 98(13), 920-931. https://doi.org/10.1093/jnci/djj246

Body size and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Pischon, Tobias; Lahmann, Petra H.; Boeing, Heiner; Friedenreich, Christine; Norat, Teresa; Tjønneland, Anne; Halkjaer, Jytte; Overvad, Kim; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Guernec, Gregory; Bergmann, Manuela M.; Linseisen, Jakob; Becker, Nikolaus; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Sieri, Sabina; Palli, Domenico; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Peeters, Petra H M; Bueno-de-Mesquita, H. Bas; Boshuizen, Hendriek C.; Van Guelpen, Bethany; Palmqvist, Richard; Berglund, Göran; Gonzalez, Carlos Alberto; Dorronsoro, Miren; Barricarte, Aurelio; Navarro, Carmen; Martinez, Carmen; Quirós, J. Ramón; Roddam, Andrew; Allen, Naomi; Bingham, Sheila; Khaw, Kay Tee; Ferrari, Pietro; Kaaks, Rudolf; Slimani, Nadia; Riboli, Elio.

In: Journal of the National Cancer Institute, Vol. 98, No. 13, 05.07.2006, p. 920-931.

Research output: Contribution to journalArticle

Pischon, T, Lahmann, PH, Boeing, H, Friedenreich, C, Norat, T, Tjønneland, A, Halkjaer, J, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, MC, Guernec, G, Bergmann, MM, Linseisen, J, Becker, N, Trichopoulou, A, Trichopoulos, D, Sieri, S, Palli, D, Tumino, R, Vineis, P, Panico, S, Peeters, PHM, Bueno-de-Mesquita, HB, Boshuizen, HC, Van Guelpen, B, Palmqvist, R, Berglund, G, Gonzalez, CA, Dorronsoro, M, Barricarte, A, Navarro, C, Martinez, C, Quirós, JR, Roddam, A, Allen, N, Bingham, S, Khaw, KT, Ferrari, P, Kaaks, R, Slimani, N & Riboli, E 2006, 'Body size and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)', Journal of the National Cancer Institute, vol. 98, no. 13, pp. 920-931. https://doi.org/10.1093/jnci/djj246
Pischon, Tobias ; Lahmann, Petra H. ; Boeing, Heiner ; Friedenreich, Christine ; Norat, Teresa ; Tjønneland, Anne ; Halkjaer, Jytte ; Overvad, Kim ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie Christine ; Guernec, Gregory ; Bergmann, Manuela M. ; Linseisen, Jakob ; Becker, Nikolaus ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Sieri, Sabina ; Palli, Domenico ; Tumino, Rosario ; Vineis, Paolo ; Panico, Salvatore ; Peeters, Petra H M ; Bueno-de-Mesquita, H. Bas ; Boshuizen, Hendriek C. ; Van Guelpen, Bethany ; Palmqvist, Richard ; Berglund, Göran ; Gonzalez, Carlos Alberto ; Dorronsoro, Miren ; Barricarte, Aurelio ; Navarro, Carmen ; Martinez, Carmen ; Quirós, J. Ramón ; Roddam, Andrew ; Allen, Naomi ; Bingham, Sheila ; Khaw, Kay Tee ; Ferrari, Pietro ; Kaaks, Rudolf ; Slimani, Nadia ; Riboli, Elio. / Body size and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). In: Journal of the National Cancer Institute. 2006 ; Vol. 98, No. 13. pp. 920-931.
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T1 - Body size and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Pischon, Tobias

AU - Lahmann, Petra H.

AU - Boeing, Heiner

AU - Friedenreich, Christine

AU - Norat, Teresa

AU - Tjønneland, Anne

AU - Halkjaer, Jytte

AU - Overvad, Kim

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie Christine

AU - Guernec, Gregory

AU - Bergmann, Manuela M.

AU - Linseisen, Jakob

AU - Becker, Nikolaus

AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Sieri, Sabina

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Panico, Salvatore

AU - Peeters, Petra H M

AU - Bueno-de-Mesquita, H. Bas

AU - Boshuizen, Hendriek C.

AU - Van Guelpen, Bethany

AU - Palmqvist, Richard

AU - Berglund, Göran

AU - Gonzalez, Carlos Alberto

AU - Dorronsoro, Miren

AU - Barricarte, Aurelio

AU - Navarro, Carmen

AU - Martinez, Carmen

AU - Quirós, J. Ramón

AU - Roddam, Andrew

AU - Allen, Naomi

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Ferrari, Pietro

AU - Kaaks, Rudolf

AU - Slimani, Nadia

AU - Riboli, Elio

PY - 2006/7/5

Y1 - 2006/7/5

N2 - Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the association between anthropometric measures and risks of colon and rectal cancer among 368 277 men and women who were free of cancer at baseline from nine countries of the European Prospective Investigation Into Cancer and Nutrition. All statistical tests were two-sided. Results: During 6.1 years of follow-up, we identified 984 and 586 patients with colon and rectal cancer, respectively. Body weight and BMI were statistically significantly associated with colon cancer risk in men (highest versus lowest quintile of BMI, relative risk [RR] = 1.55, 95% confidence interval [CI] = 1.12 to 2.15; P trend =.006) but not in women. In contrast, comparisons of the highest to the lowest quintile showed that several anthropometric measures, including waist circumference (men, RR = 1.39, 95% CI = 1.01 to 1.93; P trend = .001; women, RR = 1.48, 95% CI = 1.08 to 2.03; P trend = .008), waist-to-hip ratio (WHR; men, RR = 1.51, 95% CI = 1.06 to 2.15; P trend = .006; women, RR = 1.52, 95% CI = 1.12 to 2.05; P trend = .002), and height (men, RR = 1.40, 95% CI = 0.99 to 1.98; P trend = .04; women, RR = 1.79, 95% CI = 1.30 to 2.46; P trend

AB - Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the association between anthropometric measures and risks of colon and rectal cancer among 368 277 men and women who were free of cancer at baseline from nine countries of the European Prospective Investigation Into Cancer and Nutrition. All statistical tests were two-sided. Results: During 6.1 years of follow-up, we identified 984 and 586 patients with colon and rectal cancer, respectively. Body weight and BMI were statistically significantly associated with colon cancer risk in men (highest versus lowest quintile of BMI, relative risk [RR] = 1.55, 95% confidence interval [CI] = 1.12 to 2.15; P trend =.006) but not in women. In contrast, comparisons of the highest to the lowest quintile showed that several anthropometric measures, including waist circumference (men, RR = 1.39, 95% CI = 1.01 to 1.93; P trend = .001; women, RR = 1.48, 95% CI = 1.08 to 2.03; P trend = .008), waist-to-hip ratio (WHR; men, RR = 1.51, 95% CI = 1.06 to 2.15; P trend = .006; women, RR = 1.52, 95% CI = 1.12 to 2.05; P trend = .002), and height (men, RR = 1.40, 95% CI = 0.99 to 1.98; P trend = .04; women, RR = 1.79, 95% CI = 1.30 to 2.46; P trend

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