Abstract
The relationship between body mass measures at diagnosis and/or at different ages and ovarian cancer risk was investigated using an Italian multicentre case-control study. The study, conducted between 1992 and 1999, included 1031 cases of incident, histologically-confirmed epithelial ovarian cancer and 2411 controls admitted to the same network of hospitals for acute non-neoplastic conditions. Odds ratios (OR) and 95% confidence intervals (CI) were obtained using unconditional multiple logistic regression analyses. Weight and body mass index (BMI, kg/m2) 1 year prior to diagnosis/interview were not associated with ovarian cancer risk. A direct association emerged with waist-to-hip ratio (W/H) (OR=1.45 in the highest category), particularly among women with stage I-II cancers. Cases also had a higher BMI at age 30 years (OR=1.22). Conversely, cases had lower weight gain between age 30 years and the year prior to diagnosis/interview, both for cases with stage I-II and those with stage III-IV cancers.
Original language | English |
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Pages (from-to) | 1769-1774 |
Number of pages | 6 |
Journal | European Journal of Cancer |
Volume | 38 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2002 |
Keywords
- Body mass index
- Case-control study
- Ovarian cancer
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology