Body size indices at different ages and epithelial ovarian cancer risk

L. Dal Maso, S. Franceschi, E. Negri, E. Conti, M. Montella, S. Vaccarella, V. Canzonieri, F. Parazzini, C. La Vecchia

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between body mass measures at diagnosis and/or at different ages and ovarian cancer risk was investigated using an Italian multicentre case-control study. The study, conducted between 1992 and 1999, included 1031 cases of incident, histologically-confirmed epithelial ovarian cancer and 2411 controls admitted to the same network of hospitals for acute non-neoplastic conditions. Odds ratios (OR) and 95% confidence intervals (CI) were obtained using unconditional multiple logistic regression analyses. Weight and body mass index (BMI, kg/m2) 1 year prior to diagnosis/interview were not associated with ovarian cancer risk. A direct association emerged with waist-to-hip ratio (W/H) (OR=1.45 in the highest category), particularly among women with stage I-II cancers. Cases also had a higher BMI at age 30 years (OR=1.22). Conversely, cases had lower weight gain between age 30 years and the year prior to diagnosis/interview, both for cases with stage I-II and those with stage III-IV cancers.

Original languageEnglish
Pages (from-to)1769-1774
Number of pages6
JournalEuropean Journal of Cancer
Volume38
Issue number13
DOIs
Publication statusPublished - 2002

Keywords

  • Body mass index
  • Case-control study
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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