Body weight and glucose metabolism have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans

Antonio E. Pontiroli, Pierluigi Pizzocri, Diana Koprivec, Paola Vedani, Monica Marchi, Cinzia Arcelloni, Rita Paroni, Katherine Esposito, Dario Giugliano

Research output: Contribution to journalArticle

Abstract

Background: Endothelial dysfunction and inflammation are present in both type 2 diabetes mellitus (T2DM) and obesity. In this paper we compared the role of weight loss and of glycaemic control in determining circulating levels of ICAM-1, endothelin-1 (ET-1), and E-selectin in patients with morbid (grade 3) obesity. Methods and Results: ICAM-1, E-selectin, and ET-1 were higher in obese patients (n = 96) than in lean controls (n = 30); among obese patients, the three molecules were higher in T2DM patients (n = 26) than in patients with normal (NGT, n = 43) or impaired (IGT, n = 27) glucose tolerance. Sixty-eight obese patients had a significant weight loss induced by bariatric surgery, and showed a significant decrease in blood glucose, HbA1c and all molecules, so that ICAM-1, E-selectin, and ET-1 were not different in NGT, IGT and T2DM patients, and in lean controls; in 13 patients with a small weight loss induced by diet, changes were not significant, in spite of a significant reduction in blood glucose and HbA1c. At stepwise regression, changes in ICAM-1, ET-1, and E-selectin significantly correlated only with change in body mass index. Conclusions: These data indicate that weight loss is more important than glycaemic control in regulating circulating levels of ICAM-1, ET-1, E-selectin in morbidly obese subjects.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalEuropean Journal of Endocrinology
Volume150
Issue number2
DOIs
Publication statusPublished - Feb 2004

ASJC Scopus subject areas

  • Endocrinology

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