BOLD signal and vessel dynamics: a hierarchical cluster analysis

Girolamo Garreffa, Soléakhéna Ken, Maria Antonietta Macrì, Giovanni Giulietti, Federico Giove, Claudio Colonnese, Eugenio Venditti, Emilio De Cesare, Vittorio Galasso, Bruno Maraviglia

Research output: Contribution to journalArticlepeer-review


The aim of the present study was to analyze blood oxygenation level-dependent (BOLD) signal variation during an apnea-based task in order to assess the capability of a functional magnetic resonance imaging (fMRI) procedure to estimate cerebral vascular dynamic effects. We measured BOLD contrast by hierarchical cluster analysis in healthy subjects undergoing an fMRI experiment, in which the task paradigm was one phase of inspirational apnea (IA). By processing the time courses of the fMRI experiment, analysis was performed only on a subclass of all the possible signal patterns; basically, root mean square and absolute variation differences have been calculated. Considering the baseline value obtained by computing the mean value of the initial rest period as reference, particular voxels showed relative important variations during the IA task and during the recovery phase following the IA. We focused our interest on the signal response of voxels that would correspond mainly to white and gray matter regions and that also may be affected by the proximity of large venous vessels. The results are presented as maps of space-temporal distribution of time series variations with two levels of hierarchical clustering among voxels with low to high initial response. Furthermore, we have presented a clustering of the signal response delay, conducting to a partition and identification of specified brain sites.

Original languageEnglish
Pages (from-to)411-418
Number of pages8
JournalMagnetic Resonance Imaging
Issue number4
Publication statusPublished - May 2006


  • Apnea
  • BOLD contrast
  • Cluster analysis
  • fMRI
  • Venous blood flow

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics


Dive into the research topics of 'BOLD signal and vessel dynamics: a hierarchical cluster analysis'. Together they form a unique fingerprint.

Cite this