Bombesin inhibits growth hormone response to insulin-induced hypoglycemia in humans

Carmelo Scarpignato, Franco Tirelli, Antonio E. Pontiroli

Research output: Contribution to journalArticlepeer-review

Abstract

Intravenous administration of bombesin (5 ng/kg/min × 2.5 h) significantly reduced growth hormone (GH) response to insulin-induced (0.15 U/kg, i.v.) hypoglycemia in 8 male volunteers without affecting its basal plasma levels. These data, together with the presence of bombesin-like immunoreactivity in the human brain, suggest that - as in experimental animals - this neurogastrointestinal peptide may be of physiological significance in the control of GH secretion also in man.

Original languageEnglish
Pages (from-to)187-189
Number of pages3
JournalBrain Research
Volume371
Issue number1
DOIs
Publication statusPublished - Apr 16 1986

Keywords

  • bombesin
  • growth hormone
  • insulin hypoglycemia

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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