Bombesin-like immunoreactivity in the avian gut and its localisation to a distinct cell type

C. M. Timson, J. M. Polak, J. Wharton, M. A. Ghatei, S. R. Bloom, L. Usellini, C. Capella, E. Solcia, M. R. Brown, A. G E Pearse

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution of a bombesin-like immunoreactive peptide in the avian gastro-intestinal tract was analysed by combined radioimmunoassay and immunocytochemistry. Radioimmunoassay of tissue extracts showed that the largest quantities of bombesin-like immunoreactivity were present in the proventriculus (64.5±6.0 pmol/g) with smaller but still considerable amounts in the gizzard (40.0±6.0 pmol/g). Immunocytochemically the extractable bombesin-like immunoreactivity was localised in numerous endocrine cells. These, in the proventriculus, were found mainly in the deeper layers of the mucosa. Further study of these cells by the semi-thin/thin technique revealed the presence of characteristic secretory granules. The functional name BN is proposed for this cell type.

Original languageEnglish
Pages (from-to)213-221
Number of pages9
JournalHistochemistry
Volume61
Issue number2
DOIs
Publication statusPublished - Jan 1979

ASJC Scopus subject areas

  • Anatomy
  • Medicine(all)

Fingerprint Dive into the research topics of 'Bombesin-like immunoreactivity in the avian gut and its localisation to a distinct cell type'. Together they form a unique fingerprint.

Cite this