Peptides of the bombesin family are mitogenic for Swiss 3T3 fibroblasts and in these cells stimulate the turnover of polyphosphoinostides. Recent studies have suggested that G protein(s) may be involved in the signal transduction pathway triggered by bombesin. In this study we have found and characterized a high affinity GTPase activity stimulated by bombesin in membranes of Swiss 3T3 fibroblasts. Our results support the involvement of a G protein in the response of Swiss 3T3 cells to bombesin.
|Number of pages||4|
|Journal||Biochimica et Biophysica Acta - Molecular Cell Research|
|Publication status||Published - May 17 1991|
- G protein (Mouse fibroblast)
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology