Bombesin stimulates a high affinity GTPase activity in membranes of Swiss 3T3 fibroblasts

L. Morello, E. Sturani, M. G. Cattaneo, R. Brambilla, A. Vicario, L. Alberghina, R. Zippel

Research output: Contribution to journalArticle

Abstract

Peptides of the bombesin family are mitogenic for Swiss 3T3 fibroblasts and in these cells stimulate the turnover of polyphosphoinostides. Recent studies have suggested that G protein(s) may be involved in the signal transduction pathway triggered by bombesin. In this study we have found and characterized a high affinity GTPase activity stimulated by bombesin in membranes of Swiss 3T3 fibroblasts. Our results support the involvement of a G protein in the response of Swiss 3T3 cells to bombesin.

Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1092
Issue number3
DOIs
Publication statusPublished - May 17 1991

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Bombesin
GTP Phosphohydrolases
Fibroblasts
Membranes
GTP-Binding Proteins
Swiss 3T3 Cells
Signal Transduction
Peptides

Keywords

  • Bombesin
  • G protein (Mouse fibroblast)
  • GTPase

ASJC Scopus subject areas

  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Morello, L., Sturani, E., Cattaneo, M. G., Brambilla, R., Vicario, A., Alberghina, L., & Zippel, R. (1991). Bombesin stimulates a high affinity GTPase activity in membranes of Swiss 3T3 fibroblasts. Biochimica et Biophysica Acta - Molecular Cell Research, 1092(3), 397-400. https://doi.org/10.1016/S0167-4889(97)90018-5

Bombesin stimulates a high affinity GTPase activity in membranes of Swiss 3T3 fibroblasts. / Morello, L.; Sturani, E.; Cattaneo, M. G.; Brambilla, R.; Vicario, A.; Alberghina, L.; Zippel, R.

In: Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1092, No. 3, 17.05.1991, p. 397-400.

Research output: Contribution to journalArticle

Morello, L, Sturani, E, Cattaneo, MG, Brambilla, R, Vicario, A, Alberghina, L & Zippel, R 1991, 'Bombesin stimulates a high affinity GTPase activity in membranes of Swiss 3T3 fibroblasts', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1092, no. 3, pp. 397-400. https://doi.org/10.1016/S0167-4889(97)90018-5
Morello, L. ; Sturani, E. ; Cattaneo, M. G. ; Brambilla, R. ; Vicario, A. ; Alberghina, L. ; Zippel, R. / Bombesin stimulates a high affinity GTPase activity in membranes of Swiss 3T3 fibroblasts. In: Biochimica et Biophysica Acta - Molecular Cell Research. 1991 ; Vol. 1092, No. 3. pp. 397-400.
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