Bombesin stimulation of c-fos and c-myc gene expression in cultures of Swiss 3T3 cells

Antonio P. Palumbo, Paola Rossino, Paolo M. Comoglio

Research output: Contribution to journalArticle

Abstract

Bombesin has been shown to be a potent mitogen for Swiss 3T3 cells. At nanomolar concentrations it stimulates DNA synthesis in quiescent cultures of 3T3 cells and also induces the expression of c-fos and c-myc mRNA. c-fos mRNA transcripts dramatically increase 15 min after the addition of bombesin, are still abundant after 30-60 min and then decrease, c-myc mRNA induction is detectable later, 1 h after bombesin treatment. Conversely, no changes in c-Ki-ras expression are observed after stimulation with bombesin. These results demonstrate that the increased expression of c-fos and c-myc mRNAs appears to be a common response to diverse agents that induce DNA synthesis and cell proliferation.

Original languageEnglish
Pages (from-to)276-280
Number of pages5
JournalExperimental Cell Research
Volume167
Issue number1
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cell Biology

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