Bone adaptation of a biologically reconstructed femur after Ewing sarcoma: Long-term morphological and densitometric evolution.

Giordano Valente, Fulvia Taddei, Andrea Roncari, Enrico Schileo, Marco Manfrini

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Combining bone allografts and vascularized fibular autografts in intercalary reconstructions after resection of bone sarcomas is of particular interest in young patients as it facilitates bone healing and union and helps reduce fractures. However, adverse events related to bone adaptation still occur. Bone adaptation is driven by mechanical loading, but no quantitative biomechanical studies exist that would help surgical planning and rehabilitation. We analyzed the bone adaptation of a successful femoral reconstruction after Ewing sarcoma during 76-month follow-up using a novel methodology that allows CT-based quantification of morphology and density. The results indicated that the vital allograft promoted bone adaptation in the reconstruction. However, an overall negative balance of bone remodeling and a progressive mineral density decrease in the femoral neck might threaten long-term bone safety. These concerns seem related to both surgical technique and mechanical stimuli, where a stiff metal implant may determine load sharing, which negatively affects bone remodeling.
Original languageEnglish
Pages (from-to)1271-1276
Number of pages6
JournalSkeletal Radiology
Volume46
Issue number9
DOIs
Publication statusPublished - Apr 26 2017

Fingerprint

Ewing's Sarcoma
Femur
Bone and Bones
Bone Remodeling
Allografts
Femur Neck
Autografts
Thigh
Sarcoma
Minerals
Rehabilitation
Metals
Safety

Keywords

  • Biological reconstruction
  • Biomechanical measurements
  • Bone adaptation
  • Bone mineral density
  • Bone sarcoma

Cite this

Bone adaptation of a biologically reconstructed femur after Ewing sarcoma: Long-term morphological and densitometric evolution. / Valente, Giordano; Taddei, Fulvia; Roncari, Andrea; Schileo, Enrico; Manfrini, Marco.

In: Skeletal Radiology, Vol. 46, No. 9, 26.04.2017, p. 1271-1276.

Research output: Contribution to journalArticle

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AU - Manfrini, Marco

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