Bone age assessment in the workup of children with endocrine disorders

Gian Luigi Spadoni, Stefano Cianfarani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Bone age is a measure of developmental age, or physiological maturity, which represents more truthfully than chronological age, how far an individual has progressed towards full maturity. It is particularly helpful in the clinical workup of children with growth and/or puberty disorders as well as in treating decisions, such as whether to start replacement therapy in a patient with hypogonadism. Skeletal maturity assessment plays a pivotal role in confirming the diagnosis of normal variants of growth such as familial short stature and constitutional delay of growth, in interpreting hormone tests during puberty, and in the diagnosis of precocious puberty and hyperandrogenism. On the other hand, it is important to recognize that overemphasizing bone age evaluation can be misleading if not used in the proper settings. Adult height prediction is based on skeletal maturity assessment and can be used to predict with acceptable accuracy which adult height will be achieved by a 'normal' child. However, the predictions do not apply to children with endocrine or bone pathologies affecting growth.

Original languageEnglish
Pages (from-to)2-5
Number of pages4
JournalHormone Research in Paediatrics
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Bone and Bones
Puberty
Growth
Hyperandrogenism
Precocious Puberty
Hypogonadism
Hormones
Pathology
Therapeutics

Keywords

  • Adult height prediction
  • Bone age
  • Growth
  • Puberty
  • Short stature

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Bone age assessment in the workup of children with endocrine disorders. / Spadoni, Gian Luigi; Cianfarani, Stefano.

In: Hormone Research in Paediatrics, Vol. 73, No. 1, 01.2010, p. 2-5.

Research output: Contribution to journalArticle

@article{dc9dae67417b41fd91f015ea51d3e26f,
title = "Bone age assessment in the workup of children with endocrine disorders",
abstract = "Bone age is a measure of developmental age, or physiological maturity, which represents more truthfully than chronological age, how far an individual has progressed towards full maturity. It is particularly helpful in the clinical workup of children with growth and/or puberty disorders as well as in treating decisions, such as whether to start replacement therapy in a patient with hypogonadism. Skeletal maturity assessment plays a pivotal role in confirming the diagnosis of normal variants of growth such as familial short stature and constitutional delay of growth, in interpreting hormone tests during puberty, and in the diagnosis of precocious puberty and hyperandrogenism. On the other hand, it is important to recognize that overemphasizing bone age evaluation can be misleading if not used in the proper settings. Adult height prediction is based on skeletal maturity assessment and can be used to predict with acceptable accuracy which adult height will be achieved by a 'normal' child. However, the predictions do not apply to children with endocrine or bone pathologies affecting growth.",
keywords = "Adult height prediction, Bone age, Growth, Puberty, Short stature",
author = "Spadoni, {Gian Luigi} and Stefano Cianfarani",
year = "2010",
month = "1",
doi = "10.1159/000271910",
language = "English",
volume = "73",
pages = "2--5",
journal = "Hormone Research in Paediatrics",
issn = "1663-2818",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Bone age assessment in the workup of children with endocrine disorders

AU - Spadoni, Gian Luigi

AU - Cianfarani, Stefano

PY - 2010/1

Y1 - 2010/1

N2 - Bone age is a measure of developmental age, or physiological maturity, which represents more truthfully than chronological age, how far an individual has progressed towards full maturity. It is particularly helpful in the clinical workup of children with growth and/or puberty disorders as well as in treating decisions, such as whether to start replacement therapy in a patient with hypogonadism. Skeletal maturity assessment plays a pivotal role in confirming the diagnosis of normal variants of growth such as familial short stature and constitutional delay of growth, in interpreting hormone tests during puberty, and in the diagnosis of precocious puberty and hyperandrogenism. On the other hand, it is important to recognize that overemphasizing bone age evaluation can be misleading if not used in the proper settings. Adult height prediction is based on skeletal maturity assessment and can be used to predict with acceptable accuracy which adult height will be achieved by a 'normal' child. However, the predictions do not apply to children with endocrine or bone pathologies affecting growth.

AB - Bone age is a measure of developmental age, or physiological maturity, which represents more truthfully than chronological age, how far an individual has progressed towards full maturity. It is particularly helpful in the clinical workup of children with growth and/or puberty disorders as well as in treating decisions, such as whether to start replacement therapy in a patient with hypogonadism. Skeletal maturity assessment plays a pivotal role in confirming the diagnosis of normal variants of growth such as familial short stature and constitutional delay of growth, in interpreting hormone tests during puberty, and in the diagnosis of precocious puberty and hyperandrogenism. On the other hand, it is important to recognize that overemphasizing bone age evaluation can be misleading if not used in the proper settings. Adult height prediction is based on skeletal maturity assessment and can be used to predict with acceptable accuracy which adult height will be achieved by a 'normal' child. However, the predictions do not apply to children with endocrine or bone pathologies affecting growth.

KW - Adult height prediction

KW - Bone age

KW - Growth

KW - Puberty

KW - Short stature

UR - http://www.scopus.com/inward/record.url?scp=77951478819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951478819&partnerID=8YFLogxK

U2 - 10.1159/000271910

DO - 10.1159/000271910

M3 - Article

VL - 73

SP - 2

EP - 5

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

SN - 1663-2818

IS - 1

ER -