Bone and body composition analyzed by Dual-energy X-ray Absorptiometry (DXA) in clinical and nutritional evaluation of young patients with cystic fibrosis: A cross-sectional study

Vincenzina Lucidi, Carla Bizzarri, Federico Alghisi, Sergio Bella, Beatrice Russo, Graziamaria Ubertini, Marco Cappa

Research output: Contribution to journalArticlepeer-review

Abstract

Background: the improved general therapy has led to reduced morbidity and mortality from Cystic Fibrosis (CF), and bone status may have a potentially greater clinical impact. Methods: We investigated the correlation between the severity of the clinical condition, bone status and body composition parameters, in a group of children and young adults with CF. Results: we measured lumbar spine bone density and total body composition by dual energy x-ray absorptiometry (DXA) in 82 consecutive CF patients (42 males; median age: 13 years - range: 5-30). Eighty-two healthy subjects, matched for age, gender, height and pubertal stage were recruited as a control group. Conclusion: 37 patients (45.1%) had a normal bone mineral density (BMD). A BMD reduction were observed in 45 (54.8%) patients. Lumbar spine Z score was positively related to Body Mass Index (BMI) and a higher Shwachman-Kulczycki score, and negatively related to Crispin-Norman score. A positive and significant correlation was also observed between lumbar spine Z score and total body composition. a significant BMD reduction can be present early in CF children and adolescents. A careful follow up of bone status is required starting in childhood.

Original languageEnglish
Article number1471
Pages (from-to)61
Number of pages1
JournalBMC Pediatrics
Volume9
DOIs
Publication statusPublished - Sep 28 2009

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint

Dive into the research topics of 'Bone and body composition analyzed by Dual-energy X-ray Absorptiometry (DXA) in clinical and nutritional evaluation of young patients with cystic fibrosis: A cross-sectional study'. Together they form a unique fingerprint.

Cite this