Bone disease in long-term renal transplant recipients with severe osteopenia: A cross-sectional study

Davide Rolla, Paola Ballanti, Luigina Marsano, Gerolamo Bianchi, Piergiorgio Messa, Ernesto Paoletti, Giuseppe Cannella

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Fracture is a disabling clinical outcome after transplantation, but there is little histopathological information on long-term renal recipients with severe osteopenia. Methods. Twenty kidney recipients (8.3±1.9 years after transplantation), 13 males and 7 females (five postmenopausal) with nearly normal renal function, affected by severe osteopenia (T-score: males = -4.9±0.28; females = -5.08±0.47) underwent bone biopsy and morphometric X-ray absorptiometry to evaluate vertebral fractures. Results. Histopathological diagnosis was osteoporosis-osteopenia in seven patients, osteitis fibrosa in six, prevalent osteomalacic lesion in six, and "normal" bone in one patient. Significant increases in osteoid volume (OV/BV), osteoid surface, osteoblastic surface (ObS/BS) and osteoid thickness were observed. OV/BV and Obs/BS ratios were inversely correlated to cumulative doses of MPRED (r2=0.85 P

Original languageEnglish
Pages (from-to)915-921
Number of pages7
JournalTransplantation
Volume81
Issue number6
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Bone biopsy
  • Osteopenia
  • Renal transplantation
  • Vertebral fracture

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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