Abstract
The purpose of our study was to investigate the possible therapeutic effects of endovenous infusions of pamidronate in young patients on total parenteral nutrition (TPN) from birth. We examined 9 patients, 6 of whom presented low bone mineral density (BMD). These patients (5 males and 1 female, aged 2 to 19 years) were treated with monthly infusions of pamidronate for six consecutive months. Four patients showed improvement in BMD after pamidronate treatment, one patient's BMD was unchanged, while one patient's BMD worsened. The biochemical markers of bone turnover were not particularly different before and after pamidronate treatment, except for an increase in urinary calcium loss. The only side effect of note was hypocalcemia 1-2 days after infusion, corrected by i.v. calcium supplementation. Our preliminary data seem to indicate that pamidronate is an effective and fairly safe treatment for bone disease in patients on long-term parenteral nutrition. Pamidronate now needs to be administered for longer periods and more cases need to be recruited and monitored.
Original language | English |
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Journal | Rivista Italiana di Nutrizione Parenterale ed Enterale |
Volume | 20 |
Issue number | SUPPL. 4 |
Publication status | Published - Jul 2002 |
Keywords
- Bone mineral density
- Long term parenteral nutrition
- Pamidronate
ASJC Scopus subject areas
- Food Science
- Anatomy
- Critical Care and Intensive Care Medicine
- Nutrition and Dietetics