Bone hemangioendothelioma: An immunohistochemical study related to histological malignancy and proliferative activity (NORs)

M. S. Benassi, G. Gamberi, P. Ragazzini, M. R. Sollazzo, C. Ferrari, L. Sangiorgi, D. Trere, M. Derenzini, P. Picci

Research output: Contribution to journalArticle

Abstract

Aims and background: Forty-four bone hemangioendotheliomas (HEs) of different histological grades were studied to evaluate the expression and distribution of laminin, type IV collagen, cathepsin G and cathepsin D in cell differentiation and malignancy. Results: In poorly-differentiated HEs the discontinuous distribution of laminin and type IV collagen around angioblastic cords, tubes and cavities revealed an irregular and disorganized basement membrane (BM) architecture corresponding to an increased cell proliferation and secretion of cathepsin D and cathepsin G by tumor cells. Conclusions: The mean nucleolar organizer region (NOR) area, as a measure of cell proliferation, was significantly higher in grade 4 malignancies than in lower grades, revealing novel prognostic parameters.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalTumori
Volume81
Issue number3
Publication statusPublished - 1995

Keywords

  • Ag-NOR proteins
  • basement membrane
  • hemangioendothelioma
  • immunohistochemistry

ASJC Scopus subject areas

  • Cancer Research

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