Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

D. Ribatti, A. Vacca, B. Nico, F. Quondamatteo, R. Ria, M. Minischetti, A. Marzullo, R. Herken, L. Roncali, F. Dammacco

Research output: Contribution to journalArticle

231 Citations (Scopus)

Abstract

Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules.

Original languageEnglish
Pages (from-to)451-455
Number of pages5
JournalBritish Journal of Cancer
Volume79
Issue number3-4
DOIs
Publication statusPublished - 1999

Fingerprint

Multiple Myeloma
Mast Cells
Bone Marrow Cells
Cell Count
Monoclonal Gammopathy of Undetermined Significance
Angiogenesis Inducing Agents
Secretory Vesicles
Bone Marrow

Keywords

  • Angiogenesis
  • Mast cell
  • Multiple myeloma
  • Tumour progression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ribatti, D., Vacca, A., Nico, B., Quondamatteo, F., Ria, R., Minischetti, M., ... Dammacco, F. (1999). Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma. British Journal of Cancer, 79(3-4), 451-455. https://doi.org/10.1038/sj.bjc.6690070

Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma. / Ribatti, D.; Vacca, A.; Nico, B.; Quondamatteo, F.; Ria, R.; Minischetti, M.; Marzullo, A.; Herken, R.; Roncali, L.; Dammacco, F.

In: British Journal of Cancer, Vol. 79, No. 3-4, 1999, p. 451-455.

Research output: Contribution to journalArticle

Ribatti, D, Vacca, A, Nico, B, Quondamatteo, F, Ria, R, Minischetti, M, Marzullo, A, Herken, R, Roncali, L & Dammacco, F 1999, 'Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma', British Journal of Cancer, vol. 79, no. 3-4, pp. 451-455. https://doi.org/10.1038/sj.bjc.6690070
Ribatti, D. ; Vacca, A. ; Nico, B. ; Quondamatteo, F. ; Ria, R. ; Minischetti, M. ; Marzullo, A. ; Herken, R. ; Roncali, L. ; Dammacco, F. / Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma. In: British Journal of Cancer. 1999 ; Vol. 79, No. 3-4. pp. 451-455.
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