Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

D. Ribatti, A. Vacca, B. Nico, F. Quondamatteo, R. Ria, M. Minischetti, A. Marzullo, R. Herken, L. Roncali, F. Dammacco

Research output: Contribution to journalArticlepeer-review

Abstract

Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules.

Original languageEnglish
Pages (from-to)451-455
Number of pages5
JournalBritish Journal of Cancer
Volume79
Issue number3-4
DOIs
Publication statusPublished - 1999

Keywords

  • Angiogenesis
  • Mast cell
  • Multiple myeloma
  • Tumour progression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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