Bone marrow CD34+ cell count is predictive for adequate peripheral progenitor cell collection

Alessandro Corso, Marzia Varettoni, Silvia Mangiacavalli, Patrizia Zappasodi, Catherine Klersy, Chiara Rusconi, Emile Colucci, Angela Lorenzi, Daniela Troletti, Erica Consensi, Mario Lazzarino

Research output: Contribution to journalArticle

Abstract

Several studies have investigated the influence of clinical and biological variables on mobilisation of peripheral blood progenitor cells (PBPCs). The aim of this study was to evaluate the role of steady-state bone marrow (BM) CD34+ cells as a predictive parameter of PBPC yield. We studied 90 patients with multiple myeloma (MM) (41 patients), non-Hodgkin's lymphoma (NHL) (25 patients) or acute myeloid leukaemia (AML) (24 patients), mobilised with chemotherapy and growth factor. The median time from first treatment to mobilisation was 5 months. Only one patient was previously exposed to alkylating agents. The median BM CD34+ count at mobilisation was 833 μl -1 (range:1.4-15.540) corresponding to 1.51% of mononuclear cells (range: 0.02-8.6). Sixty-six patients (73%) reached the optimal target of 4 × 10 6 kg -1 CD34+ cells with 1 (18 patients), 2 (42 patients) or 3 leukaphereses (6 patients). Eleven patients (12%) mobilised less than 4 × 10 6 kg -1 CD34+ cells and 13 (15%) failed mobilisation. Among the laboratory and clinical parameters evaluated at the time of mobilisation, only BM CD34+ count was a predictive factor for adequate collection (P = 0.04), particularly in MM patients (P = 0.003). In this setting, a BM concentration of CD34+ cells lower than 66 μL -1 was associated with a higher probability of inadequate collection.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalLeukemia Research
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 2005

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Keywords

  • CD34+ cells
  • Lymphoma
  • Multiple myeloma
  • Peripheral stem cell collection
  • Transplant

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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