Bone marrow CD34+ progenitor cells may harbour HIV-DNA even in successfully treated patients

Research output: Contribution to journalArticlepeer-review

Abstract

The issue about bone marrow hematopoietic progenitor cells harbouring HIV-DNA in infected patients is still under scrutiny. We studied nine HIV-infected individuals undergoing bone marrow aspiration for diagnostic purposes. In all patients, even in those receiving successful antiretroviral therapy for several years, HIV-DNA was detected in purified CD34+ lineage-bone marrow progenitor cells. This finding, although not conclusive due to the low number of patients examined, adds further evidence that current treatment strategies may be insufficient to resolve latent infection in bone marrow CD34+ hematopoietic progenitor cells.

Original languageEnglish
Pages (from-to)290.e5-290.e8
JournalClinical Microbiology and Infection
Volume21
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Bone marrow
  • Hematopoietic progenitor cells
  • HIV infection
  • Proviral DNA
  • Viral load

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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