Abstract
In addition to its well-established use for hematopoiesis reconstitution, bone marrow is considered with increasing interest as a possible source of mature cells for adoptive therapies, in particular for the immunotherapy of cancer. Nevertheless, the peculiarities of bone marrow T cells in comparison with those in lymphoid periphery are still largely unknown. In this report, we show for the first time that bone marrow CD8 T cells are in a different activation state than those in peripheral lymphoid organs. Firstly, we observed that mouse bone marrow contains a significantly higher percentage of blasts within the CD8 T cells than either spleen or lymph nodes, yet such enrichment is not due to recent antigenic stimulation. Secondly, when we challenged bone marrow CD8 T cells from immunized mice with their antigen in vitro, they displayed a faster response than those from the spleen. Thus, we suggest that the bone marrow could be a preferential source of CD8 T cells for adoptive therapies in those cases in which highly active effectors are required.
| Original language | English |
|---|---|
| Pages (from-to) | 1873-1880 |
| Number of pages | 8 |
| Journal | European Journal of Immunology |
| Volume | 32 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2002 |
Fingerprint
Keywords
- Bone marrow transplantation
- Cellular activation
- Immunological memory
- T lymphocyte
ASJC Scopus subject areas
- Immunology
Cite this
Bone marrow CD8 T cells are in different activation state than those in lymphoid periphery. / Di Rosa, Francesca; Santoni, Angela.
In: European Journal of Immunology, Vol. 32, No. 7, 2002, p. 1873-1880.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone marrow CD8 T cells are in different activation state than those in lymphoid periphery
AU - Di Rosa, Francesca
AU - Santoni, Angela
PY - 2002
Y1 - 2002
N2 - In addition to its well-established use for hematopoiesis reconstitution, bone marrow is considered with increasing interest as a possible source of mature cells for adoptive therapies, in particular for the immunotherapy of cancer. Nevertheless, the peculiarities of bone marrow T cells in comparison with those in lymphoid periphery are still largely unknown. In this report, we show for the first time that bone marrow CD8 T cells are in a different activation state than those in peripheral lymphoid organs. Firstly, we observed that mouse bone marrow contains a significantly higher percentage of blasts within the CD8 T cells than either spleen or lymph nodes, yet such enrichment is not due to recent antigenic stimulation. Secondly, when we challenged bone marrow CD8 T cells from immunized mice with their antigen in vitro, they displayed a faster response than those from the spleen. Thus, we suggest that the bone marrow could be a preferential source of CD8 T cells for adoptive therapies in those cases in which highly active effectors are required.
AB - In addition to its well-established use for hematopoiesis reconstitution, bone marrow is considered with increasing interest as a possible source of mature cells for adoptive therapies, in particular for the immunotherapy of cancer. Nevertheless, the peculiarities of bone marrow T cells in comparison with those in lymphoid periphery are still largely unknown. In this report, we show for the first time that bone marrow CD8 T cells are in a different activation state than those in peripheral lymphoid organs. Firstly, we observed that mouse bone marrow contains a significantly higher percentage of blasts within the CD8 T cells than either spleen or lymph nodes, yet such enrichment is not due to recent antigenic stimulation. Secondly, when we challenged bone marrow CD8 T cells from immunized mice with their antigen in vitro, they displayed a faster response than those from the spleen. Thus, we suggest that the bone marrow could be a preferential source of CD8 T cells for adoptive therapies in those cases in which highly active effectors are required.
KW - Bone marrow transplantation
KW - Cellular activation
KW - Immunological memory
KW - T lymphocyte
UR - http://www.scopus.com/inward/record.url?scp=0036316236&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036316236&partnerID=8YFLogxK
U2 - 10.1002/1521-4141(200207)32:7<1873::AID-IMMU1873>3.0.CO;2-P
DO - 10.1002/1521-4141(200207)32:7<1873::AID-IMMU1873>3.0.CO;2-P
M3 - Article
VL - 32
SP - 1873
EP - 1880
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
IS - 7
ER -