Bone marrow donor-related variables associated with harvest outcome in HLA-haploidentical transplantation with postinfusion cyclophosphamide

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Abstract

Background and objectives: Several transplantation outcomes have been shown to be associated with the infused bone marrow cell dose/kg of the recipient's body weight. The donor bone marrow density is directly related to the infused cell dose. The aim of the present study was to identify donor-related variables that are associated with high donor bone marrow density. Materials and methods: We retrospectively analysed the predictive factors of high marrow density in 65 consecutive HLA-haploidentical bone marrow donors harvested at our centre between 2009 and 2013. Results: Body mass index (BMI) and peripheral white blood cell (WBC) count were directly associated with bone marrow density (regression coefficient β = 5·33 and β = 2·93, respectively; P <0·01). The likelihood of obtaining a collection with a high density was first predicted using BMI (BMI ≥30, mean density = 25·8 TNC/ml × 106). Second, donors with a BMI 3/mm3: mean density = 18·4 TNC/ml × 106; WBC ≥8 × 103/mm3: mean density = 23·1 TNC/ml × 106). We also observed that the density of the first collected bag directly correlated with the overall density (R2 = 0·69, P <0·01). Conclusion: The donor-related features BMI and WBC count affect the cell quantity obtainable with the harvest and should be taken into account when choosing the donor.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalVox Sanguinis
Volume111
Issue number1
DOIs
Publication statusPublished - Jul 1 2016

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Keywords

  • bone marrow density
  • bone marrow donors
  • donor selection
  • haploidentical transplantation
  • predictive collection tree

ASJC Scopus subject areas

  • Hematology

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