Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells

Antonio Pellegrino, Roberto Ria, Giulia Di Pietro, Teresa Cirulli, Giammarco Surico, Angela Pennisi, Fortunato Morabito, Domenico Ribatti, Angelo Vacca

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Bone marrow endothelial cells (EC) from patients with multiple myeloma (MM) were found to express and secrete higher amounts of the CXC-chemokines CXCLS/interleukin (IL)-8, CXCL11/interferon-inducible T-cell alpha chemoattractant (I-TAC), CXCL12/stromal cell-derived factor (SDF)-1α, and CCL2/monocyte chemotactic protein(MCP)-1 than EC from human umbilical vein (HUVEC), considered as a healthy counterpart. Paired plasma cells and several MM cell lines expressed cognate receptors of each chemokine to a variable extent. When cells were exposed to chemokines, CXCL8/IL-8 and CXCL12/SDF-1α stimulated their proliferation and all chemokines stimulated cell chemotaxis. It is suggested that angiogenesis also favours MM progression through the release of CXC-chemokines.

Original languageEnglish
Pages (from-to)248-256
Number of pages9
JournalBritish Journal of Haematology
Volume129
Issue number2
DOIs
Publication statusPublished - Apr 2005

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CXC Chemokines
Plasma Cells
Multiple Myeloma
Interleukin-8
Bone Marrow Cells
Chemokine CXCL12
Endothelial Cells
Chemokine CCL2
Chemokine Receptors
Chemotactic Factors
Human Umbilical Vein Endothelial Cells
Chemotaxis
Chemokines
Interferons
T-Lymphocytes
Cell Line

Keywords

  • CXC-chemokines
  • CXCRs
  • Multiple myeloma
  • Plasma cells
  • Tumour progression

ASJC Scopus subject areas

  • Hematology

Cite this

Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells. / Pellegrino, Antonio; Ria, Roberto; Di Pietro, Giulia; Cirulli, Teresa; Surico, Giammarco; Pennisi, Angela; Morabito, Fortunato; Ribatti, Domenico; Vacca, Angelo.

In: British Journal of Haematology, Vol. 129, No. 2, 04.2005, p. 248-256.

Research output: Contribution to journalArticle

Pellegrino, A, Ria, R, Di Pietro, G, Cirulli, T, Surico, G, Pennisi, A, Morabito, F, Ribatti, D & Vacca, A 2005, 'Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells', British Journal of Haematology, vol. 129, no. 2, pp. 248-256. https://doi.org/10.1111/j.1365-2141.2005.05443.x
Pellegrino, Antonio ; Ria, Roberto ; Di Pietro, Giulia ; Cirulli, Teresa ; Surico, Giammarco ; Pennisi, Angela ; Morabito, Fortunato ; Ribatti, Domenico ; Vacca, Angelo. / Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells. In: British Journal of Haematology. 2005 ; Vol. 129, No. 2. pp. 248-256.
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