Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells

Antonio Pellegrino, Roberto Ria, Giulia Di Pietro, Teresa Cirulli, Giammarco Surico, Angela Pennisi, Fortunato Morabito, Domenico Ribatti, Angelo Vacca

Research output: Contribution to journalArticle

Abstract

Bone marrow endothelial cells (EC) from patients with multiple myeloma (MM) were found to express and secrete higher amounts of the CXC-chemokines CXCLS/interleukin (IL)-8, CXCL11/interferon-inducible T-cell alpha chemoattractant (I-TAC), CXCL12/stromal cell-derived factor (SDF)-1α, and CCL2/monocyte chemotactic protein(MCP)-1 than EC from human umbilical vein (HUVEC), considered as a healthy counterpart. Paired plasma cells and several MM cell lines expressed cognate receptors of each chemokine to a variable extent. When cells were exposed to chemokines, CXCL8/IL-8 and CXCL12/SDF-1α stimulated their proliferation and all chemokines stimulated cell chemotaxis. It is suggested that angiogenesis also favours MM progression through the release of CXC-chemokines.

Original languageEnglish
Pages (from-to)248-256
Number of pages9
JournalBritish Journal of Haematology
Volume129
Issue number2
DOIs
Publication statusPublished - Apr 2005

Keywords

  • CXC-chemokines
  • CXCRs
  • Multiple myeloma
  • Plasma cells
  • Tumour progression

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Pellegrino, A., Ria, R., Di Pietro, G., Cirulli, T., Surico, G., Pennisi, A., Morabito, F., Ribatti, D., & Vacca, A. (2005). Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells. British Journal of Haematology, 129(2), 248-256. https://doi.org/10.1111/j.1365-2141.2005.05443.x