Abstract
The dominant pathophysiological and clinical features of myeloproliferative neoplasm (MPN)-associated myelofibrosis are caused by bone marrow fibrosis. It is widely believed this fibrosis is a reaction to the MPN-clone implying the cells causing fibrosis are polyclonal and genetically unrelated to the MPN-clone. We cite recent data illustrating the complexity of cell types comprising the bone marrow micro-environment and showing that at least some of the cells responsible for bone marrow fibrosis are clonal and genetically related to the MPN-clone.
Original language | English |
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Pages (from-to) | 563-565 |
Number of pages | 3 |
Journal | Leukemia Research |
Volume | 35 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2011 |
Keywords
- Clonality
- Fibroblasts
- MPN
- Myelofibrosis
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology