Abstract
The dominant pathophysiological and clinical features of myeloproliferative neoplasm (MPN)-associated myelofibrosis are caused by bone marrow fibrosis. It is widely believed this fibrosis is a reaction to the MPN-clone implying the cells causing fibrosis are polyclonal and genetically unrelated to the MPN-clone. We cite recent data illustrating the complexity of cell types comprising the bone marrow micro-environment and showing that at least some of the cells responsible for bone marrow fibrosis are clonal and genetically related to the MPN-clone.
| Original language | English |
|---|---|
| Pages (from-to) | 563-565 |
| Number of pages | 3 |
| Journal | Leukemia Research |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2011 |
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Keywords
- Clonality
- Fibroblasts
- MPN
- Myelofibrosis
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Bone marrow fibrosis in myeloproliferative neoplasms-associated myelofibrosis : Deconstructing a myth? / Barosi, Giovanni; Gale, Robert Peter.
In: Leukemia Research, Vol. 35, No. 5, 05.2011, p. 563-565.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone marrow fibrosis in myeloproliferative neoplasms-associated myelofibrosis
T2 - Deconstructing a myth?
AU - Barosi, Giovanni
AU - Gale, Robert Peter
PY - 2011/5
Y1 - 2011/5
N2 - The dominant pathophysiological and clinical features of myeloproliferative neoplasm (MPN)-associated myelofibrosis are caused by bone marrow fibrosis. It is widely believed this fibrosis is a reaction to the MPN-clone implying the cells causing fibrosis are polyclonal and genetically unrelated to the MPN-clone. We cite recent data illustrating the complexity of cell types comprising the bone marrow micro-environment and showing that at least some of the cells responsible for bone marrow fibrosis are clonal and genetically related to the MPN-clone.
AB - The dominant pathophysiological and clinical features of myeloproliferative neoplasm (MPN)-associated myelofibrosis are caused by bone marrow fibrosis. It is widely believed this fibrosis is a reaction to the MPN-clone implying the cells causing fibrosis are polyclonal and genetically unrelated to the MPN-clone. We cite recent data illustrating the complexity of cell types comprising the bone marrow micro-environment and showing that at least some of the cells responsible for bone marrow fibrosis are clonal and genetically related to the MPN-clone.
KW - Clonality
KW - Fibroblasts
KW - MPN
KW - Myelofibrosis
UR - http://www.scopus.com/inward/record.url?scp=79954625832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954625832&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2011.01.013
DO - 10.1016/j.leukres.2011.01.013
M3 - Article
C2 - 21296418
AN - SCOPUS:79954625832
VL - 35
SP - 563
EP - 565
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 5
ER -