Bone marrow fibrosis in myeloproliferative neoplasms-associated myelofibrosis: Deconstructing a myth?

Giovanni Barosi, Robert Peter Gale

Research output: Contribution to journalArticlepeer-review

Abstract

The dominant pathophysiological and clinical features of myeloproliferative neoplasm (MPN)-associated myelofibrosis are caused by bone marrow fibrosis. It is widely believed this fibrosis is a reaction to the MPN-clone implying the cells causing fibrosis are polyclonal and genetically unrelated to the MPN-clone. We cite recent data illustrating the complexity of cell types comprising the bone marrow micro-environment and showing that at least some of the cells responsible for bone marrow fibrosis are clonal and genetically related to the MPN-clone.

Original languageEnglish
Pages (from-to)563-565
Number of pages3
JournalLeukemia Research
Volume35
Issue number5
DOIs
Publication statusPublished - May 2011

Keywords

  • Clonality
  • Fibroblasts
  • MPN
  • Myelofibrosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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