Bone marrow histological modifications induced by alpha interferon in hairy cell leukemia

G. Lambertenghi-Deliliers, E. Benazzi, A. Cortelezzi, E. E. Polli

Research output: Contribution to journalArticle

Abstract

This paper reports the bone marrow histological picture in 7 patients with hairy cell leukemia treated with recombinant interferon. Bone marrow biopsies were performed at diagnosis, after 1, 3 and 7 months from the beginning of treatment and at 12 months at treatment suspension. The main modifications observed were a conspicuous reduction of hairy cell infiltrate, profound hypoplasia induced by the drug, early evidence of focal erythropoiesis followed by the appearance of other hematopoietic series and a progressive reduction of the reticulum. The clinical response to interferon therapy was good in all the patients studied; however future studies will have to evaluate the duration of response after treatment suspension.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalActa Haematologica
Volume77
Issue number4
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Hematology

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    Lambertenghi-Deliliers, G., Benazzi, E., Cortelezzi, A., & Polli, E. E. (1987). Bone marrow histological modifications induced by alpha interferon in hairy cell leukemia. Acta Haematologica, 77(4), 203-207.