Bone marrow infiltration by liposarcoma cells. Case report

Unusual bone marrow infiltration by malignant cells from a myxoid liposarcoma of the thigh, in a 74-yr-old man, is reported. Detection of malignant cells in bone marrow biopsy material from the posterior iliac crest or in an aspirate from the sternum occurred at the time of a third recurrence of the tumor. Aspirate smears revealed the malignant cells to vary greatly in size and in shape; the cytoplasm was abundant and contained lipid deposits oil red O-positive and small blocks of PAS-positive material. The detection of bone marrow involvement coincided with the wide spread evidence of the disease.