Localizzazione di microfilarie di Mansonella perstants nel midollo osseo

Translated title of the contribution: Bone marrow infiltration of Mansonella perstans microfilariae

Enrico Rino Bregani, C. Ghiringhelli, T. Ceraldi, A. Rovellini

Research output: Contribution to journalArticlepeer-review


Mansonella perstans is a human filarial parasite, widely distributed in the center of Africa, and intertropical America. It is transmitted by midges of the genus Culicoides. Adult worms reside in the body cavities and in the mesentery, perirenal, and retroperitoneal tissues. Microfilariae circulate in the blood without regular periodicity, M. perstans infection was long thought to be asymptomatic, subsequent studies, however, indicate clearly that M. perstans is capable of inducing a variety of symptoms, including angioedemas swellings, pruritus, fever, headache, pain in bursae and/or joint synovia, or in serous cavities. A case of M. perstans infection with recovery of microfilariae in bone marrow is described in an old man with myelodisplastic syndrome probably due to a lymphoma. Even if a blood contamination is likely in bone marrow aspiration technic, the differential count of nucleated cells shows a prevalence of bone marrow precursor, with little or no contamination of peripheral blood. The high amount of microfilariae in the sample suggests the possibility of the passage of microfilariae in the bone marrow, or a possibie bone marrow localization of adult worms. A bone biopsy could better evaluate these hypothesis.

Translated title of the contributionBone marrow infiltration of Mansonella perstans microfilariae
Original languageItalian
Pages (from-to)127-129
Number of pages3
JournalGiornale Italiano di Medicina Tropicale
Issue number3-4
Publication statusPublished - Jul 2001

ASJC Scopus subject areas

  • Infectious Diseases

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