Bone marrow microenvironment and the progression of multiple myeloma

F. Caligaris-Cappio, M. G. Gregoretti, F. Merico, D. Gottardi, P. Ghia, G. Parvis, L. Bergui

Research output: Contribution to journalArticlepeer-review


The BM microenvironment in MM, in terms of adhesive features, is well organized to entrap circulating precursors with BM-seeking properties and is able to produce cytokines that offer them the optimal conditions for local growth and final differentiation. Likewise, the malignant B cell clone is equipped with adhesion molecules which enable the cell to establish close contacts with BM stromal cells. Furthermore a number of cytokines are released including IL-1β and M-CSF activating ∥ BM stromal cells ∥ to produce other cytokines, such as IL-6, that stimulate the proliferation of plasma cells. Finally, most cytokines produced locally, including IL-1/β TNF-K, M-CSF, IL-3 and IL-6, also have OAF properties, explaining why the expansion of the B cell clone parallels the activation and numerical increase of the osteoclast population.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalLeukemia and Lymphoma
Issue number1-2
Publication statusPublished - 1992


  • Adhesion molecules
  • B lymphocytes
  • Cytokines
  • Plasma cells
  • Stromal cells

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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