Bone marrow stromal damage after chemo/radiotherapy

Occurence, consequences and possibilities of treatment

A. Banfi, G. Bianchi, M. Galotto, R. Cancedda, R. Quarto

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

High dose chemotherapy (CT) followed by bone marrow transplant (BMT) is increasingly used for the treatment of both hematological and solid neoplasms, but an understanding of its late consequences on the marrow microenvironment is still only at its beginning. It is in fact known that marrow stroma is damaged by high-dose cytotoxic therapy and by radiation exposure. However little is known on the extent of this damage and on the self-repair ability of the stroma. The damage of the stromal microenvironment affects the long-term stem cell engraftment and the maintenance of hemopoietic functions. Furthermore, marrow stroma also represents a progenitor compartment for endosteal osteoblasts, and therefore its damage implies alterations of bone metabolism. Indeed, osteoporosis has recently been recognized as a consequence, of BMT, but only a few studies have been performed to establish the functional status of the stromal compartment after treatment with cytotoxic drugs with or without total body irradiation (TBI) and its role in post-BMT sequelae.

Original languageEnglish
Pages (from-to)863-870
Number of pages8
JournalLeukemia and Lymphoma
Volume42
Issue number5
Publication statusPublished - 2001

Fingerprint

Radiotherapy
Bone Marrow
Transplants
Therapeutics
Whole-Body Irradiation
Hematologic Neoplasms
Osteoblasts
Osteoporosis
Stem Cells
Maintenance
Bone and Bones
Drug Therapy
Pharmaceutical Preparations

Keywords

  • Bone marrow stromal cells
  • Chemotherapy
  • Marrow stroma
  • Stroma transplant

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Bone marrow stromal damage after chemo/radiotherapy : Occurence, consequences and possibilities of treatment. / Banfi, A.; Bianchi, G.; Galotto, M.; Cancedda, R.; Quarto, R.

In: Leukemia and Lymphoma, Vol. 42, No. 5, 2001, p. 863-870.

Research output: Contribution to journalArticle

Banfi, A. ; Bianchi, G. ; Galotto, M. ; Cancedda, R. ; Quarto, R. / Bone marrow stromal damage after chemo/radiotherapy : Occurence, consequences and possibilities of treatment. In: Leukemia and Lymphoma. 2001 ; Vol. 42, No. 5. pp. 863-870.
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