Bone marrow transplantation and thymopoietin pentapeptide treatment in two infants with immunodeficiency with predominant T-cell defects

Luisa Businco, P. Rossi, R. Paganelli, Elena Galli, G. DiGilio, Patrizia Lulli, F. Aiuti

Research output: Contribution to journalArticle

Abstract

Two infants with immunodeficiency with predominant T-cell defects received transplants of HLA-identical bone marrow cells along with thymopoietin pentapeptide (TP-5) treatment and no prior immunosuppressive therapy. Both patients achieved durable engraftment with early reconstitution of cell-mediated immunity. The study of cell surface antigens with monoclonal antibodies (MoAb) revealed that the early appearance of T-cell subsets defined by OKT4 and OKT8 MoAb occurred. Neither of the patients showed any signs or symptoms of graft versus host disease over a 1-year period. This experience suggests that patients with T-cell deficiency who do not benefit from thymic hormones alone can be successfully treated by bone marrow transplantation. The association of TP-5 with bone marrow transplantation seems to induce and early and stable reconstitution and to protect against fatal post-transplant infection.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalClinical Immunology and Immunopathology
Volume33
Issue number1
DOIs
Publication statusPublished - 1984

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Thymopentin
Bone Marrow Transplantation
T-Lymphocytes
Monoclonal Antibodies
Thymus Hormones
Transplants
T-Lymphocyte Subsets
Graft vs Host Disease
Surface Antigens
Immunosuppressive Agents
Cellular Immunity
Bone Marrow Cells
Signs and Symptoms
Therapeutics
Infection

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Bone marrow transplantation and thymopoietin pentapeptide treatment in two infants with immunodeficiency with predominant T-cell defects. / Businco, Luisa; Rossi, P.; Paganelli, R.; Galli, Elena; DiGilio, G.; Lulli, Patrizia; Aiuti, F.

In: Clinical Immunology and Immunopathology, Vol. 33, No. 1, 1984, p. 123-130.

Research output: Contribution to journalArticle

Businco, Luisa ; Rossi, P. ; Paganelli, R. ; Galli, Elena ; DiGilio, G. ; Lulli, Patrizia ; Aiuti, F. / Bone marrow transplantation and thymopoietin pentapeptide treatment in two infants with immunodeficiency with predominant T-cell defects. In: Clinical Immunology and Immunopathology. 1984 ; Vol. 33, No. 1. pp. 123-130.
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