Bone marrow transplantation for severe aplastic anemia: A report of 9 cases

Alberto M. Marmont; M. T. Van Lint; G. Avanzi; G. Reali; R. Adami; A. Soldá; P. Strada; M. Barbanti; M. C. Mingari; O. Soro; G. Grazi; D. Pedullá; R. Cerri; E. Rossi; D. Giordano; G. Santini; A. Carella; M. Risso; R. Vimercati; G. Piaggio; M. R. Raffo; E. Librace; V. Vitale; A. Bacigalupo

doi:10.1159/000207557

Bone marrow transplantation for severe aplastic anemia: A report of 9 cases

Alberto M. Marmont, M. T. Van Lint, G. Avanzi, G. Reali, R. Adami, A. Soldá, P. Strada, M. Barbanti, M. C. Mingari, O. Soro, G. Grazi, D. Pedullá, R. Cerri, E. Rossi, D. Giordano, G. Santini, A. Carella, M. Risso, R. Vimercati, G. PiaggioM. R. Raffo, E. Librace, V. Vitale, A. Bacigalupo

Research output: Contribution to journal › Article › peer-review

Abstract

9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT). 5 were conditioned with cyclophosphamide and received and HLA-identical graft (4 patients) or a mismatched graft (1 patient): 1 rejected the graft on day 30 and died on day 34 during conditioning for a second transplant; 1 died on day 15 with acute and severe graft versus host disease (GvHD) in the absence of haemopoietic engraftment; 3 are alive and complete chimeras at 1,069, 490 and 332 days after transplantation. GvHD developed in 4 patients and was treated successfully in 3 with high dose methylprednisolone and/or antilymphocytic globulin (ALG). 4 patients were conditioned with ALG and received bone marrow from a haploidentical sibling or parent: 1 patient was refractory; 3 patients showed evidence of hematologic reconstitution, but 2 of these required a second course of ALG. 3 patients in this group are alive between 60 and 490 days; 1 patient died on day 121 of HBSAg-negative acute hepatitis.

Original language	English
Pages (from-to)	121-127
Number of pages	7
Journal	Acta Haematologica
Volume	62
Issue number	3
DOIs	https://doi.org/10.1159/000207557
Publication status	Published - 1979

Keywords

Aplastic anemia
Bone marrow transplantation

ASJC Scopus subject areas

Hematology

Access to Document

10.1159/000207557

Fingerprint Dive into the research topics of 'Bone marrow transplantation for severe aplastic anemia: A report of 9 cases'. Together they form a unique fingerprint.

Cite this

Marmont, A. M., Van Lint, M. T., Avanzi, G., Reali, G., Adami, R., Soldá, A., Strada, P., Barbanti, M., Mingari, M. C., Soro, O., Grazi, G., Pedullá, D., Cerri, R., Rossi, E., Giordano, D., Santini, G., Carella, A., Risso, M., Vimercati, R., ... Bacigalupo, A. (1979). Bone marrow transplantation for severe aplastic anemia: A report of 9 cases. Acta Haematologica, 62(3), 121-127. https://doi.org/10.1159/000207557

Bone marrow transplantation for severe aplastic anemia : A report of 9 cases. / Marmont, Alberto M.; Van Lint, M. T.; Avanzi, G.; Reali, G.; Adami, R.; Soldá, A.; Strada, P.; Barbanti, M.; Mingari, M. C.; Soro, O.; Grazi, G.; Pedullá, D.; Cerri, R.; Rossi, E.; Giordano, D.; Santini, G.; Carella, A.; Risso, M.; Vimercati, R.; Piaggio, G.; Raffo, M. R.; Librace, E.; Vitale, V.; Bacigalupo, A.

In: Acta Haematologica, Vol. 62, No. 3, 1979, p. 121-127.

Research output: Contribution to journal › Article › peer-review

Marmont, AM, Van Lint, MT, Avanzi, G, Reali, G, Adami, R, Soldá, A, Strada, P, Barbanti, M, Mingari, MC, Soro, O, Grazi, G, Pedullá, D, Cerri, R, Rossi, E, Giordano, D, Santini, G, Carella, A, Risso, M, Vimercati, R, Piaggio, G, Raffo, MR, Librace, E, Vitale, V & Bacigalupo, A 1979, 'Bone marrow transplantation for severe aplastic anemia: A report of 9 cases', Acta Haematologica, vol. 62, no. 3, pp. 121-127. https://doi.org/10.1159/000207557

Marmont, Alberto M. ; Van Lint, M. T. ; Avanzi, G. ; Reali, G. ; Adami, R. ; Soldá, A. ; Strada, P. ; Barbanti, M. ; Mingari, M. C. ; Soro, O. ; Grazi, G. ; Pedullá, D. ; Cerri, R. ; Rossi, E. ; Giordano, D. ; Santini, G. ; Carella, A. ; Risso, M. ; Vimercati, R. ; Piaggio, G. ; Raffo, M. R. ; Librace, E. ; Vitale, V. ; Bacigalupo, A. / Bone marrow transplantation for severe aplastic anemia : A report of 9 cases. In: Acta Haematologica. 1979 ; Vol. 62, No. 3. pp. 121-127.

@article{ac4634f059144f3cbbd8a2df9485996d,

title = "Bone marrow transplantation for severe aplastic anemia: A report of 9 cases",

abstract = "9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT). 5 were conditioned with cyclophosphamide and received and HLA-identical graft (4 patients) or a mismatched graft (1 patient): 1 rejected the graft on day 30 and died on day 34 during conditioning for a second transplant; 1 died on day 15 with acute and severe graft versus host disease (GvHD) in the absence of haemopoietic engraftment; 3 are alive and complete chimeras at 1,069, 490 and 332 days after transplantation. GvHD developed in 4 patients and was treated successfully in 3 with high dose methylprednisolone and/or antilymphocytic globulin (ALG). 4 patients were conditioned with ALG and received bone marrow from a haploidentical sibling or parent: 1 patient was refractory; 3 patients showed evidence of hematologic reconstitution, but 2 of these required a second course of ALG. 3 patients in this group are alive between 60 and 490 days; 1 patient died on day 121 of HBSAg-negative acute hepatitis.",

keywords = "Aplastic anemia, Bone marrow transplantation",

author = "Marmont, {Alberto M.} and {Van Lint}, {M. T.} and G. Avanzi and G. Reali and R. Adami and A. Sold{\'a} and P. Strada and M. Barbanti and Mingari, {M. C.} and O. Soro and G. Grazi and D. Pedull{\'a} and R. Cerri and E. Rossi and D. Giordano and G. Santini and A. Carella and M. Risso and R. Vimercati and G. Piaggio and Raffo, {M. R.} and E. Librace and V. Vitale and A. Bacigalupo",

year = "1979",

doi = "10.1159/000207557",

language = "English",

volume = "62",

pages = "121--127",

journal = "Acta Haematologica",

issn = "0001-5792",

publisher = "S. Karger AG",

number = "3",

}

TY - JOUR

T1 - Bone marrow transplantation for severe aplastic anemia

T2 - A report of 9 cases

AU - Marmont, Alberto M.

AU - Van Lint, M. T.

AU - Avanzi, G.

AU - Reali, G.

AU - Adami, R.

AU - Soldá, A.

AU - Strada, P.

AU - Barbanti, M.

AU - Mingari, M. C.

AU - Soro, O.

AU - Grazi, G.

AU - Pedullá, D.

AU - Cerri, R.

AU - Rossi, E.

AU - Giordano, D.

AU - Santini, G.

AU - Carella, A.

AU - Risso, M.

AU - Vimercati, R.

AU - Piaggio, G.

AU - Raffo, M. R.

AU - Librace, E.

AU - Vitale, V.

AU - Bacigalupo, A.

PY - 1979

Y1 - 1979

N2 - 9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT). 5 were conditioned with cyclophosphamide and received and HLA-identical graft (4 patients) or a mismatched graft (1 patient): 1 rejected the graft on day 30 and died on day 34 during conditioning for a second transplant; 1 died on day 15 with acute and severe graft versus host disease (GvHD) in the absence of haemopoietic engraftment; 3 are alive and complete chimeras at 1,069, 490 and 332 days after transplantation. GvHD developed in 4 patients and was treated successfully in 3 with high dose methylprednisolone and/or antilymphocytic globulin (ALG). 4 patients were conditioned with ALG and received bone marrow from a haploidentical sibling or parent: 1 patient was refractory; 3 patients showed evidence of hematologic reconstitution, but 2 of these required a second course of ALG. 3 patients in this group are alive between 60 and 490 days; 1 patient died on day 121 of HBSAg-negative acute hepatitis.

AB - 9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT). 5 were conditioned with cyclophosphamide and received and HLA-identical graft (4 patients) or a mismatched graft (1 patient): 1 rejected the graft on day 30 and died on day 34 during conditioning for a second transplant; 1 died on day 15 with acute and severe graft versus host disease (GvHD) in the absence of haemopoietic engraftment; 3 are alive and complete chimeras at 1,069, 490 and 332 days after transplantation. GvHD developed in 4 patients and was treated successfully in 3 with high dose methylprednisolone and/or antilymphocytic globulin (ALG). 4 patients were conditioned with ALG and received bone marrow from a haploidentical sibling or parent: 1 patient was refractory; 3 patients showed evidence of hematologic reconstitution, but 2 of these required a second course of ALG. 3 patients in this group are alive between 60 and 490 days; 1 patient died on day 121 of HBSAg-negative acute hepatitis.

KW - Aplastic anemia

KW - Bone marrow transplantation

UR - http://www.scopus.com/inward/record.url?scp=0018677625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018677625&partnerID=8YFLogxK

U2 - 10.1159/000207557

DO - 10.1159/000207557

M3 - Article

C2 - 43062

AN - SCOPUS:0018677625

VL - 62

SP - 121

EP - 127

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 3

ER -