Bone marrow transplantation for severe aplastic anemia: A report of 9 cases

Alberto M. Marmont, M. T. Van Lint, G. Avanzi, G. Reali, R. Adami, A. Soldá, P. Strada, M. Barbanti, M. C. Mingari, O. Soro, G. Grazi, D. Pedullá, R. Cerri, E. Rossi, D. Giordano, G. Santini, A. Carella, M. Risso, R. Vimercati, G. PiaggioM. R. Raffo, E. Librace, V. Vitale, A. Bacigalupo

Research output: Contribution to journalArticlepeer-review

Abstract

9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT). 5 were conditioned with cyclophosphamide and received and HLA-identical graft (4 patients) or a mismatched graft (1 patient): 1 rejected the graft on day 30 and died on day 34 during conditioning for a second transplant; 1 died on day 15 with acute and severe graft versus host disease (GvHD) in the absence of haemopoietic engraftment; 3 are alive and complete chimeras at 1,069, 490 and 332 days after transplantation. GvHD developed in 4 patients and was treated successfully in 3 with high dose methylprednisolone and/or antilymphocytic globulin (ALG). 4 patients were conditioned with ALG and received bone marrow from a haploidentical sibling or parent: 1 patient was refractory; 3 patients showed evidence of hematologic reconstitution, but 2 of these required a second course of ALG. 3 patients in this group are alive between 60 and 490 days; 1 patient died on day 121 of HBSAg-negative acute hepatitis.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalActa Haematologica
Volume62
Issue number3
DOIs
Publication statusPublished - 1979

Keywords

  • Aplastic anemia
  • Bone marrow transplantation

ASJC Scopus subject areas

  • Hematology

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