Abstract
9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT). 5 were conditioned with cyclophosphamide and received and HLA-identical graft (4 patients) or a mismatched graft (1 patient): 1 rejected the graft on day 30 and died on day 34 during conditioning for a second transplant; 1 died on day 15 with acute and severe graft versus host disease (GvHD) in the absence of haemopoietic engraftment; 3 are alive and complete chimeras at 1,069, 490 and 332 days after transplantation. GvHD developed in 4 patients and was treated successfully in 3 with high dose methylprednisolone and/or antilymphocytic globulin (ALG). 4 patients were conditioned with ALG and received bone marrow from a haploidentical sibling or parent: 1 patient was refractory; 3 patients showed evidence of hematologic reconstitution, but 2 of these required a second course of ALG. 3 patients in this group are alive between 60 and 490 days; 1 patient died on day 121 of HBSAg-negative acute hepatitis.
| Original language | English |
|---|---|
| Pages (from-to) | 121-127 |
| Number of pages | 7 |
| Journal | Acta Haematologica |
| Volume | 62 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1979 |
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Keywords
- Aplastic anemia
- Bone marrow transplantation
ASJC Scopus subject areas
- Hematology
Cite this
Bone marrow transplantation for severe aplastic anemia : A report of 9 cases. / Marmont, Alberto M.; Van Lint, M. T.; Avanzi, G.; Reali, G.; Adami, R.; Soldá, A.; Strada, P.; Barbanti, M.; Mingari, M. C.; Soro, O.; Grazi, G.; Pedullá, D.; Cerri, R.; Rossi, E.; Giordano, D.; Santini, G.; Carella, A.; Risso, M.; Vimercati, R.; Piaggio, G.; Raffo, M. R.; Librace, E.; Vitale, V.; Bacigalupo, A.
In: Acta Haematologica, Vol. 62, No. 3, 1979, p. 121-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone marrow transplantation for severe aplastic anemia
T2 - A report of 9 cases
AU - Marmont, Alberto M.
AU - Van Lint, M. T.
AU - Avanzi, G.
AU - Reali, G.
AU - Adami, R.
AU - Soldá, A.
AU - Strada, P.
AU - Barbanti, M.
AU - Mingari, M. C.
AU - Soro, O.
AU - Grazi, G.
AU - Pedullá, D.
AU - Cerri, R.
AU - Rossi, E.
AU - Giordano, D.
AU - Santini, G.
AU - Carella, A.
AU - Risso, M.
AU - Vimercati, R.
AU - Piaggio, G.
AU - Raffo, M. R.
AU - Librace, E.
AU - Vitale, V.
AU - Bacigalupo, A.
PY - 1979
Y1 - 1979
N2 - 9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT). 5 were conditioned with cyclophosphamide and received and HLA-identical graft (4 patients) or a mismatched graft (1 patient): 1 rejected the graft on day 30 and died on day 34 during conditioning for a second transplant; 1 died on day 15 with acute and severe graft versus host disease (GvHD) in the absence of haemopoietic engraftment; 3 are alive and complete chimeras at 1,069, 490 and 332 days after transplantation. GvHD developed in 4 patients and was treated successfully in 3 with high dose methylprednisolone and/or antilymphocytic globulin (ALG). 4 patients were conditioned with ALG and received bone marrow from a haploidentical sibling or parent: 1 patient was refractory; 3 patients showed evidence of hematologic reconstitution, but 2 of these required a second course of ALG. 3 patients in this group are alive between 60 and 490 days; 1 patient died on day 121 of HBSAg-negative acute hepatitis.
AB - 9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT). 5 were conditioned with cyclophosphamide and received and HLA-identical graft (4 patients) or a mismatched graft (1 patient): 1 rejected the graft on day 30 and died on day 34 during conditioning for a second transplant; 1 died on day 15 with acute and severe graft versus host disease (GvHD) in the absence of haemopoietic engraftment; 3 are alive and complete chimeras at 1,069, 490 and 332 days after transplantation. GvHD developed in 4 patients and was treated successfully in 3 with high dose methylprednisolone and/or antilymphocytic globulin (ALG). 4 patients were conditioned with ALG and received bone marrow from a haploidentical sibling or parent: 1 patient was refractory; 3 patients showed evidence of hematologic reconstitution, but 2 of these required a second course of ALG. 3 patients in this group are alive between 60 and 490 days; 1 patient died on day 121 of HBSAg-negative acute hepatitis.
KW - Aplastic anemia
KW - Bone marrow transplantation
UR - http://www.scopus.com/inward/record.url?scp=0018677625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018677625&partnerID=8YFLogxK
U2 - 10.1159/000207557
DO - 10.1159/000207557
M3 - Article
C2 - 43062
AN - SCOPUS:0018677625
VL - 62
SP - 121
EP - 127
JO - Acta Haematologica
JF - Acta Haematologica
SN - 0001-5792
IS - 3
ER -