Abstract
A 25-year-old female with achondroplastic dwarfism, diagnosed when she was six months old, was diagnosed with chronic myeloid leukemia (CML) in chronic phase with 9;22 translocation, A2B3 gene rearrangment and a Sokal index of 0.5. A recombinant interferon-α2A treatment was started in October '94, which obtained a hematological, but not a karyotypic, response at the 6th and 12th month. In August '94, the patient was submitted to allogeneic bone marrow transplantation (alloBMT) from a 36-year-old matched sibling. The procedure was well tolerated. Disease-free survival (DFS) and overall survival (OS) were 21 and 39 months, respectively. We have not found any reported cases of achondroplastic patients submitted to alloBMT in the literature or in the IBMT Registry.
| Original language | English |
|---|---|
| Pages (from-to) | 703-704 |
| Number of pages | 2 |
| Journal | Haematologica |
| Volume | 82 |
| Issue number | 6 |
| Publication status | Published - Nov 1997 |
Fingerprint
Keywords
- Achondroplasia
- Allogeneic bone marrow transplantation
- Chronic myeloid leukemia
- Radiations
ASJC Scopus subject areas
- Hematology
Cite this
Bone marrow transplantation in a patient with chronic myeloid leukemia and achondroplasia. / Geromin, Antonella; Sperotto, Alessandra; Fanin, Renato; Damiani, Daniela; Michieli, Mariagrazia; Baccarani, Michele.
In: Haematologica, Vol. 82, No. 6, 11.1997, p. 703-704.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone marrow transplantation in a patient with chronic myeloid leukemia and achondroplasia
AU - Geromin, Antonella
AU - Sperotto, Alessandra
AU - Fanin, Renato
AU - Damiani, Daniela
AU - Michieli, Mariagrazia
AU - Baccarani, Michele
PY - 1997/11
Y1 - 1997/11
N2 - A 25-year-old female with achondroplastic dwarfism, diagnosed when she was six months old, was diagnosed with chronic myeloid leukemia (CML) in chronic phase with 9;22 translocation, A2B3 gene rearrangment and a Sokal index of 0.5. A recombinant interferon-α2A treatment was started in October '94, which obtained a hematological, but not a karyotypic, response at the 6th and 12th month. In August '94, the patient was submitted to allogeneic bone marrow transplantation (alloBMT) from a 36-year-old matched sibling. The procedure was well tolerated. Disease-free survival (DFS) and overall survival (OS) were 21 and 39 months, respectively. We have not found any reported cases of achondroplastic patients submitted to alloBMT in the literature or in the IBMT Registry.
AB - A 25-year-old female with achondroplastic dwarfism, diagnosed when she was six months old, was diagnosed with chronic myeloid leukemia (CML) in chronic phase with 9;22 translocation, A2B3 gene rearrangment and a Sokal index of 0.5. A recombinant interferon-α2A treatment was started in October '94, which obtained a hematological, but not a karyotypic, response at the 6th and 12th month. In August '94, the patient was submitted to allogeneic bone marrow transplantation (alloBMT) from a 36-year-old matched sibling. The procedure was well tolerated. Disease-free survival (DFS) and overall survival (OS) were 21 and 39 months, respectively. We have not found any reported cases of achondroplastic patients submitted to alloBMT in the literature or in the IBMT Registry.
KW - Achondroplasia
KW - Allogeneic bone marrow transplantation
KW - Chronic myeloid leukemia
KW - Radiations
UR - http://www.scopus.com/inward/record.url?scp=0031453532&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031453532&partnerID=8YFLogxK
M3 - Article
C2 - 9499671
AN - SCOPUS:0031453532
VL - 82
SP - 703
EP - 704
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 6
ER -