Bone marrow transplantation in a patient with chronic myeloid leukemia and achondroplasia

Antonella Geromin, Alessandra Sperotto, Renato Fanin, Daniela Damiani, Mariagrazia Michieli, Michele Baccarani

Research output: Contribution to journalArticlepeer-review


A 25-year-old female with achondroplastic dwarfism, diagnosed when she was six months old, was diagnosed with chronic myeloid leukemia (CML) in chronic phase with 9;22 translocation, A2B3 gene rearrangment and a Sokal index of 0.5. A recombinant interferon-α2A treatment was started in October '94, which obtained a hematological, but not a karyotypic, response at the 6th and 12th month. In August '94, the patient was submitted to allogeneic bone marrow transplantation (alloBMT) from a 36-year-old matched sibling. The procedure was well tolerated. Disease-free survival (DFS) and overall survival (OS) were 21 and 39 months, respectively. We have not found any reported cases of achondroplastic patients submitted to alloBMT in the literature or in the IBMT Registry.

Original languageEnglish
Pages (from-to)703-704
Number of pages2
Issue number6
Publication statusPublished - Nov 1997


  • Achondroplasia
  • Allogeneic bone marrow transplantation
  • Chronic myeloid leukemia
  • Radiations

ASJC Scopus subject areas

  • Hematology


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