Bone marrow transplantation in a patient with chronic myeloid leukemia and achondroplasia

Antonella Geromin; Alessandra Sperotto; Renato Fanin; Daniela Damiani; Mariagrazia Michieli; Michele Baccarani

Bone marrow transplantation in a patient with chronic myeloid leukemia and achondroplasia

Antonella Geromin, Alessandra Sperotto, Renato Fanin, Daniela Damiani, Mariagrazia Michieli, Michele Baccarani

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

A 25-year-old female with achondroplastic dwarfism, diagnosed when she was six months old, was diagnosed with chronic myeloid leukemia (CML) in chronic phase with 9;22 translocation, A2B3 gene rearrangment and a Sokal index of 0.5. A recombinant interferon-α2A treatment was started in October '94, which obtained a hematological, but not a karyotypic, response at the 6th and 12th month. In August '94, the patient was submitted to allogeneic bone marrow transplantation (alloBMT) from a 36-year-old matched sibling. The procedure was well tolerated. Disease-free survival (DFS) and overall survival (OS) were 21 and 39 months, respectively. We have not found any reported cases of achondroplastic patients submitted to alloBMT in the literature or in the IBMT Registry.

Original language	English
Pages (from-to)	703-704
Number of pages	2
Journal	Haematologica
Volume	82
Issue number	6
Publication status	Published - Nov 1997

Keywords

Achondroplasia
Allogeneic bone marrow transplantation
Chronic myeloid leukemia
Radiations

ASJC Scopus subject areas

Hematology

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title = "Bone marrow transplantation in a patient with chronic myeloid leukemia and achondroplasia",

abstract = "A 25-year-old female with achondroplastic dwarfism, diagnosed when she was six months old, was diagnosed with chronic myeloid leukemia (CML) in chronic phase with 9;22 translocation, A2B3 gene rearrangment and a Sokal index of 0.5. A recombinant interferon-α2A treatment was started in October '94, which obtained a hematological, but not a karyotypic, response at the 6th and 12th month. In August '94, the patient was submitted to allogeneic bone marrow transplantation (alloBMT) from a 36-year-old matched sibling. The procedure was well tolerated. Disease-free survival (DFS) and overall survival (OS) were 21 and 39 months, respectively. We have not found any reported cases of achondroplastic patients submitted to alloBMT in the literature or in the IBMT Registry.",

keywords = "Achondroplasia, Allogeneic bone marrow transplantation, Chronic myeloid leukemia, Radiations",

author = "Antonella Geromin and Alessandra Sperotto and Renato Fanin and Daniela Damiani and Mariagrazia Michieli and Michele Baccarani",

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AU - Geromin, Antonella

AU - Sperotto, Alessandra

AU - Fanin, Renato

AU - Damiani, Daniela

AU - Michieli, Mariagrazia

AU - Baccarani, Michele

PY - 1997/11

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N2 - A 25-year-old female with achondroplastic dwarfism, diagnosed when she was six months old, was diagnosed with chronic myeloid leukemia (CML) in chronic phase with 9;22 translocation, A2B3 gene rearrangment and a Sokal index of 0.5. A recombinant interferon-α2A treatment was started in October '94, which obtained a hematological, but not a karyotypic, response at the 6th and 12th month. In August '94, the patient was submitted to allogeneic bone marrow transplantation (alloBMT) from a 36-year-old matched sibling. The procedure was well tolerated. Disease-free survival (DFS) and overall survival (OS) were 21 and 39 months, respectively. We have not found any reported cases of achondroplastic patients submitted to alloBMT in the literature or in the IBMT Registry.

AB - A 25-year-old female with achondroplastic dwarfism, diagnosed when she was six months old, was diagnosed with chronic myeloid leukemia (CML) in chronic phase with 9;22 translocation, A2B3 gene rearrangment and a Sokal index of 0.5. A recombinant interferon-α2A treatment was started in October '94, which obtained a hematological, but not a karyotypic, response at the 6th and 12th month. In August '94, the patient was submitted to allogeneic bone marrow transplantation (alloBMT) from a 36-year-old matched sibling. The procedure was well tolerated. Disease-free survival (DFS) and overall survival (OS) were 21 and 39 months, respectively. We have not found any reported cases of achondroplastic patients submitted to alloBMT in the literature or in the IBMT Registry.

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KW - Allogeneic bone marrow transplantation

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KW - Radiations

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