Il trapianto di midollo osseo nei difetti congeniti dell'immunità.

Translated title of the contribution: Bone marrow transplantation in congenital defects of immunity

F. Porta, L. D. Notarangelo, F. Candotti, E. Mazzolari, A. Lanfranchi, A. G. Ugazio

Research output: Contribution to journalArticlepeer-review


BMT can cure several congenital immunological defects: if in these disease the engrafting is easier, the GVH reactions are more frequent and severe. The possibility to deplete from T lymphocyte the marrow before infusion, has overcame this difficulty. From 1968 183 BMT have been performed in Europe on patients with SCID (70 from HLA-identical donor, 113 from HLA-nonidentical donor). The survival after 2 years is 76% in the first group, and 56% in the second group (100 marrows have been T-depleted with different techniques). Strict isolation procedures before the transplant are very important to achieve good results. The possibility to treat different immunodeficiency With BMT are also discussed.

Translated title of the contributionBone marrow transplantation in congenital defects of immunity
Original languageItalian
Pages (from-to)27-30
Number of pages4
JournalPediatria Medica e Chirurgica
Issue number1
Publication statusPublished - Jan 1991

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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