Bone marrow transplantation in multiple myeloma

S. Tura, M. Cavo, M. Baccarani, P. Ricci, M. Gobbi

Research output: Contribution to journalArticle

Abstract

We report 3 cases of allogeneic bone marrow transplantation in multiple myeloma that we have recently performed. Following conditioning treatment with i.v. cyclophosphamide (60 mg/kg/d, for 2 d), oral melphalan (1.0 mg/kg/d, for 5 d), i.v. BCNU (5.5 mg/kg, in a single dose) and total body irradiation (10 Gy in a single fraction) we observed in all 3 cases the disappearance both of serum M component and of monoclonal bone marrow plasma cells. 1 patient died of actue GVH disease, grade IV, at 2 months, while the other 2 patients are in good health and in unmaintained complete remission at 4 and 20 months, respectively. The usefulness of allogeneic bone marrow transplantation in the management of multiple myeloma is emphasized.

Original languageEnglish
Pages (from-to)176-179
Number of pages4
JournalScandinavian Journal of Haematology
Volume36
Issue number2
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Hematology

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    Tura, S., Cavo, M., Baccarani, M., Ricci, P., & Gobbi, M. (1986). Bone marrow transplantation in multiple myeloma. Scandinavian Journal of Haematology, 36(2), 176-179.