Bone mass and long-term monophasic oral contraceptive treatment in young women

Franco Polatti; Francesca Perotti; Nadia Filippa; Davide Gallina; Rossella E. Nappi

doi:10.1016/0010-7824(95)00036-A

Bone mass and long-term monophasic oral contraceptive treatment in young women

Franco Polatti, Francesca Perotti, Nadia Filippa, Davide Gallina, Rossella E. Nappi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article

Abstract

A prospective study has been designed to investigate bone metabolism in young women taking an oral monophasic contraceptive formulation (ethinylestradiol 20 μg + desogestrel 0.150 mg) over 5 years. Healthy women (n = 200) between 19 and 22 years of age were divided into two groups. Group A received oral contraception, Group B did not receive any treatment. All the subjects underwent a bone mass density (BMD) evaluation at spinal level L2-L4 with Dexa (Norland XR-26) and a measurement of the serum alkaline phosphatase levels and urinary excretion of OH-proline at baseline and every 12 months over 5 years. Our results demonstrated that Group A did not show any significant BMD change after 5 years of oral contraceptive treatment, while Group B demonstrated a significant increase (p

Original language	English
Pages (from-to)	221-224
Number of pages	4
Journal	Contraception
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/0010-7824(95)00036-A
Publication status	Published - 1995

Keywords

alkaline phosphatase
bone mass density
monophasic contraceptive
urinary excretion

ASJC Scopus subject areas

Obstetrics and Gynaecology
Reproductive Medicine
Medicine(all)

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Polatti, F., Perotti, F., Filippa, N., Gallina, D., & Nappi, R. E. (1995). Bone mass and long-term monophasic oral contraceptive treatment in young women. Contraception, 51(4), 221-224. https://doi.org/10.1016/0010-7824(95)00036-A

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