Abstract
A prospective study has been designed to investigate bone metabolism in young women taking an oral monophasic contraceptive formulation (ethinylestradiol 20 μg + desogestrel 0.150 mg) over 5 years. Healthy women (n = 200) between 19 and 22 years of age were divided into two groups. Group A received oral contraception, Group B did not receive any treatment. All the subjects underwent a bone mass density (BMD) evaluation at spinal level L2-L4 with Dexa (Norland XR-26) and a measurement of the serum alkaline phosphatase levels and urinary excretion of OH-proline at baseline and every 12 months over 5 years. Our results demonstrated that Group A did not show any significant BMD change after 5 years of oral contraceptive treatment, while Group B demonstrated a significant increase (p
Original language | English |
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Pages (from-to) | 221-224 |
Number of pages | 4 |
Journal | Contraception |
Volume | 51 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1995 |
Keywords
- alkaline phosphatase
- bone mass density
- monophasic contraceptive
- urinary excretion
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Reproductive Medicine
- Medicine(all)