Bone metastases from head and neck malignancies: Prognostic factors and skeletal-related events

Salvatore Grisanti, Susanna Bianchi, Laura D. Locati, Luca Triggiani, Stefania Vecchio, Alberto Bonetta, Cristiana Bergamini, Pierfranco Conte, Mario Airoldi, Marco Merlano, Paolo Carlini, Toni Ibrahim, Ciro Rossetto, Salvatore Alfieri, Paolo Pronzato, Sandro Tonoli, Roberto Maroldi, Piero Nicolai, Carlo Resteghini, Stefano M. MagriniAlfredo Berruti

Research output: Contribution to journalArticle

Abstract

Background We conducted a multicenter retrospective analysis to describe the characteristics, frequency of skeletal-related events (SREs), and prognosis of head and neck cancer (HNC) in patients with bone metastases (BM). Patients and methods The data of 192 HNC patients with BMs were collected. Analyses were conducted separately in 64 nasopharyngeal cancer (NPC) patients and in 128 non-NPC patients. Results SREs occurred in 34 (27%) non-NPC and in 6 (9%) NPC patients, respectively. Median overall survival (OS) was 25 and 6 months in NPC and non-NPC patients, respectively. Locoregional recurrence (hazard ratio [HR] 2.33, 95% confidence interval (CI) 1.1–4.93), synchronous BM (HR 0.25, 95% CI 0.59–0.71) and bone-directed therapies (BDT) (HR 0.26, 95% CI 0.10–0.68) were independent prognostic factors for OS in NPC patients. Combined bone radiotherapy (RT) and BDT in NPC patients obtained longer survival (38 months) than either therapy alone (25 months) or neither of these therapies (8 months). Conclusions Patients with BMs from non-NPC have a poor prognosis and are at high risk of SREs. NPC patients with BMs are at relatively low risk of SREs. BDT may potentially improve survival, particularly when combined with bone RT. This last finding deserves prospective confirmation.

Original languageEnglish
Article numbere0213934
JournalPLoS One
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 1 2019

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metastasis
neck
Bone
Neck
Nasopharyngeal Neoplasms
Head
bones
Neoplasm Metastasis
Bone and Bones
neoplasms
Neoplasms
Hazards
Radiotherapy
therapeutics
confidence interval
Survival
radiotherapy
Confidence Intervals
Head and Neck Neoplasms
prognosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Grisanti, S., Bianchi, S., Locati, L. D., Triggiani, L., Vecchio, S., Bonetta, A., ... Berruti, A. (2019). Bone metastases from head and neck malignancies: Prognostic factors and skeletal-related events. PLoS One, 14(3), [e0213934]. https://doi.org/10.1371/journal.pone.0213934

Bone metastases from head and neck malignancies : Prognostic factors and skeletal-related events. / Grisanti, Salvatore; Bianchi, Susanna; Locati, Laura D.; Triggiani, Luca; Vecchio, Stefania; Bonetta, Alberto; Bergamini, Cristiana; Conte, Pierfranco; Airoldi, Mario; Merlano, Marco; Carlini, Paolo; Ibrahim, Toni; Rossetto, Ciro; Alfieri, Salvatore; Pronzato, Paolo; Tonoli, Sandro; Maroldi, Roberto; Nicolai, Piero; Resteghini, Carlo; Magrini, Stefano M.; Berruti, Alfredo.

In: PLoS One, Vol. 14, No. 3, e0213934, 01.03.2019.

Research output: Contribution to journalArticle

Grisanti, S, Bianchi, S, Locati, LD, Triggiani, L, Vecchio, S, Bonetta, A, Bergamini, C, Conte, P, Airoldi, M, Merlano, M, Carlini, P, Ibrahim, T, Rossetto, C, Alfieri, S, Pronzato, P, Tonoli, S, Maroldi, R, Nicolai, P, Resteghini, C, Magrini, SM & Berruti, A 2019, 'Bone metastases from head and neck malignancies: Prognostic factors and skeletal-related events', PLoS One, vol. 14, no. 3, e0213934. https://doi.org/10.1371/journal.pone.0213934
Grisanti, Salvatore ; Bianchi, Susanna ; Locati, Laura D. ; Triggiani, Luca ; Vecchio, Stefania ; Bonetta, Alberto ; Bergamini, Cristiana ; Conte, Pierfranco ; Airoldi, Mario ; Merlano, Marco ; Carlini, Paolo ; Ibrahim, Toni ; Rossetto, Ciro ; Alfieri, Salvatore ; Pronzato, Paolo ; Tonoli, Sandro ; Maroldi, Roberto ; Nicolai, Piero ; Resteghini, Carlo ; Magrini, Stefano M. ; Berruti, Alfredo. / Bone metastases from head and neck malignancies : Prognostic factors and skeletal-related events. In: PLoS One. 2019 ; Vol. 14, No. 3.
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abstract = "Background We conducted a multicenter retrospective analysis to describe the characteristics, frequency of skeletal-related events (SREs), and prognosis of head and neck cancer (HNC) in patients with bone metastases (BM). Patients and methods The data of 192 HNC patients with BMs were collected. Analyses were conducted separately in 64 nasopharyngeal cancer (NPC) patients and in 128 non-NPC patients. Results SREs occurred in 34 (27{\%}) non-NPC and in 6 (9{\%}) NPC patients, respectively. Median overall survival (OS) was 25 and 6 months in NPC and non-NPC patients, respectively. Locoregional recurrence (hazard ratio [HR] 2.33, 95{\%} confidence interval (CI) 1.1–4.93), synchronous BM (HR 0.25, 95{\%} CI 0.59–0.71) and bone-directed therapies (BDT) (HR 0.26, 95{\%} CI 0.10–0.68) were independent prognostic factors for OS in NPC patients. Combined bone radiotherapy (RT) and BDT in NPC patients obtained longer survival (38 months) than either therapy alone (25 months) or neither of these therapies (8 months). Conclusions Patients with BMs from non-NPC have a poor prognosis and are at high risk of SREs. NPC patients with BMs are at relatively low risk of SREs. BDT may potentially improve survival, particularly when combined with bone RT. This last finding deserves prospective confirmation.",
author = "Salvatore Grisanti and Susanna Bianchi and Locati, {Laura D.} and Luca Triggiani and Stefania Vecchio and Alberto Bonetta and Cristiana Bergamini and Pierfranco Conte and Mario Airoldi and Marco Merlano and Paolo Carlini and Toni Ibrahim and Ciro Rossetto and Salvatore Alfieri and Paolo Pronzato and Sandro Tonoli and Roberto Maroldi and Piero Nicolai and Carlo Resteghini and Magrini, {Stefano M.} and Alfredo Berruti",
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T2 - Prognostic factors and skeletal-related events

AU - Grisanti, Salvatore

AU - Bianchi, Susanna

AU - Locati, Laura D.

AU - Triggiani, Luca

AU - Vecchio, Stefania

AU - Bonetta, Alberto

AU - Bergamini, Cristiana

AU - Conte, Pierfranco

AU - Airoldi, Mario

AU - Merlano, Marco

AU - Carlini, Paolo

AU - Ibrahim, Toni

AU - Rossetto, Ciro

AU - Alfieri, Salvatore

AU - Pronzato, Paolo

AU - Tonoli, Sandro

AU - Maroldi, Roberto

AU - Nicolai, Piero

AU - Resteghini, Carlo

AU - Magrini, Stefano M.

AU - Berruti, Alfredo

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background We conducted a multicenter retrospective analysis to describe the characteristics, frequency of skeletal-related events (SREs), and prognosis of head and neck cancer (HNC) in patients with bone metastases (BM). Patients and methods The data of 192 HNC patients with BMs were collected. Analyses were conducted separately in 64 nasopharyngeal cancer (NPC) patients and in 128 non-NPC patients. Results SREs occurred in 34 (27%) non-NPC and in 6 (9%) NPC patients, respectively. Median overall survival (OS) was 25 and 6 months in NPC and non-NPC patients, respectively. Locoregional recurrence (hazard ratio [HR] 2.33, 95% confidence interval (CI) 1.1–4.93), synchronous BM (HR 0.25, 95% CI 0.59–0.71) and bone-directed therapies (BDT) (HR 0.26, 95% CI 0.10–0.68) were independent prognostic factors for OS in NPC patients. Combined bone radiotherapy (RT) and BDT in NPC patients obtained longer survival (38 months) than either therapy alone (25 months) or neither of these therapies (8 months). Conclusions Patients with BMs from non-NPC have a poor prognosis and are at high risk of SREs. NPC patients with BMs are at relatively low risk of SREs. BDT may potentially improve survival, particularly when combined with bone RT. This last finding deserves prospective confirmation.

AB - Background We conducted a multicenter retrospective analysis to describe the characteristics, frequency of skeletal-related events (SREs), and prognosis of head and neck cancer (HNC) in patients with bone metastases (BM). Patients and methods The data of 192 HNC patients with BMs were collected. Analyses were conducted separately in 64 nasopharyngeal cancer (NPC) patients and in 128 non-NPC patients. Results SREs occurred in 34 (27%) non-NPC and in 6 (9%) NPC patients, respectively. Median overall survival (OS) was 25 and 6 months in NPC and non-NPC patients, respectively. Locoregional recurrence (hazard ratio [HR] 2.33, 95% confidence interval (CI) 1.1–4.93), synchronous BM (HR 0.25, 95% CI 0.59–0.71) and bone-directed therapies (BDT) (HR 0.26, 95% CI 0.10–0.68) were independent prognostic factors for OS in NPC patients. Combined bone radiotherapy (RT) and BDT in NPC patients obtained longer survival (38 months) than either therapy alone (25 months) or neither of these therapies (8 months). Conclusions Patients with BMs from non-NPC have a poor prognosis and are at high risk of SREs. NPC patients with BMs are at relatively low risk of SREs. BDT may potentially improve survival, particularly when combined with bone RT. This last finding deserves prospective confirmation.

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