Bone metastases in patients with metastatic renal cell carcinoma: Are they always associated with poor prognosis?

Matteo Santoni, Alessandro Conti, Giuseppe Procopio, Camillo Porta, Toni Ibrahim, Sandro Barni, Francesco Maria Guida, Andrea Fontana, Alfredo Berruti, Rossana Berardi, Francesco Massari, Bruno Vincenzi, Cinzia Ortega, Davide Ottaviani, Giacomo Carteni, Gaetano Lanzetta, Delia De Lisi, Nicola Silvestris, Maria Antonietta Satolli, Elena CollovàAntonio Russo, Giuseppe Badalamenti, Stefano Luzi Fedeli, Francesca Maria Tanca, Vincenzo Adamo, Evaristo Maiello, Roberto Sabbatini, Alessandra Felici, Saverio Cinieri, Rodolfo Montironi, Sergio Bracarda, Giuseppe Tonini, Stefano Cascinu, Daniele Santini

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose: Aim of this study was to investigate for the presence of existing prognostic factors in patients with bone metastases (BMs) from RCC since bone represents an unfavorable site of metastasis for renal cell carcinoma (mRCC). Materials and methods: Data of patients with BMs from RCC were retrospectively collected. Age, sex, ECOG-Performance Status (PS), MSKCC group, tumor histology, presence of concomitant metastases to other sites, time from nephrectomy to bone metastases (TTBM, classified into three groups: 5 years) and time from BMs to skeletal-related event (SRE) were included in the Cox analysis to investigate their prognostic relevance. Results: 470 patients were enrolled in this analysis. In 19 patients (4%),bone was the only metastatic site; 277 patients had concomitant metastases in other sites. Median time to BMs was 16 months (range 0 - 44y) with Median OS of 17 months. Number of metastatic sites (including bone, p = 0.01), concomitant metastases, high Fuhrman grade (p <0.001) and non-clear cell histology (p = 0.013) were significantly associated with poor prognosis. Patients with TTBM >5 years had longer OS (22 months) compared to patients with TTBM

Original languageEnglish
Article number0122
JournalJournal of Experimental and Clinical Cancer Research
Volume34
Issue number1
DOIs
Publication statusPublished - 2015

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Renal Cell Carcinoma
Neoplasm Metastasis
Bone and Bones
Nephrectomy
Histology

Keywords

  • Bone metastasis
  • Prognostic factors
  • Renal cell carcinoma
  • Time to distant metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bone metastases in patients with metastatic renal cell carcinoma : Are they always associated with poor prognosis? / Santoni, Matteo; Conti, Alessandro; Procopio, Giuseppe; Porta, Camillo; Ibrahim, Toni; Barni, Sandro; Guida, Francesco Maria; Fontana, Andrea; Berruti, Alfredo; Berardi, Rossana; Massari, Francesco; Vincenzi, Bruno; Ortega, Cinzia; Ottaviani, Davide; Carteni, Giacomo; Lanzetta, Gaetano; De Lisi, Delia; Silvestris, Nicola; Satolli, Maria Antonietta; Collovà, Elena; Russo, Antonio; Badalamenti, Giuseppe; Fedeli, Stefano Luzi; Tanca, Francesca Maria; Adamo, Vincenzo; Maiello, Evaristo; Sabbatini, Roberto; Felici, Alessandra; Cinieri, Saverio; Montironi, Rodolfo; Bracarda, Sergio; Tonini, Giuseppe; Cascinu, Stefano; Santini, Daniele.

In: Journal of Experimental and Clinical Cancer Research, Vol. 34, No. 1, 0122, 2015.

Research output: Contribution to journalArticle

Santoni, M, Conti, A, Procopio, G, Porta, C, Ibrahim, T, Barni, S, Guida, FM, Fontana, A, Berruti, A, Berardi, R, Massari, F, Vincenzi, B, Ortega, C, Ottaviani, D, Carteni, G, Lanzetta, G, De Lisi, D, Silvestris, N, Satolli, MA, Collovà, E, Russo, A, Badalamenti, G, Fedeli, SL, Tanca, FM, Adamo, V, Maiello, E, Sabbatini, R, Felici, A, Cinieri, S, Montironi, R, Bracarda, S, Tonini, G, Cascinu, S & Santini, D 2015, 'Bone metastases in patients with metastatic renal cell carcinoma: Are they always associated with poor prognosis?', Journal of Experimental and Clinical Cancer Research, vol. 34, no. 1, 0122. https://doi.org/10.1186/s13046-015-0122-0
Santoni, Matteo ; Conti, Alessandro ; Procopio, Giuseppe ; Porta, Camillo ; Ibrahim, Toni ; Barni, Sandro ; Guida, Francesco Maria ; Fontana, Andrea ; Berruti, Alfredo ; Berardi, Rossana ; Massari, Francesco ; Vincenzi, Bruno ; Ortega, Cinzia ; Ottaviani, Davide ; Carteni, Giacomo ; Lanzetta, Gaetano ; De Lisi, Delia ; Silvestris, Nicola ; Satolli, Maria Antonietta ; Collovà, Elena ; Russo, Antonio ; Badalamenti, Giuseppe ; Fedeli, Stefano Luzi ; Tanca, Francesca Maria ; Adamo, Vincenzo ; Maiello, Evaristo ; Sabbatini, Roberto ; Felici, Alessandra ; Cinieri, Saverio ; Montironi, Rodolfo ; Bracarda, Sergio ; Tonini, Giuseppe ; Cascinu, Stefano ; Santini, Daniele. / Bone metastases in patients with metastatic renal cell carcinoma : Are they always associated with poor prognosis?. In: Journal of Experimental and Clinical Cancer Research. 2015 ; Vol. 34, No. 1.
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abstract = "Purpose: Aim of this study was to investigate for the presence of existing prognostic factors in patients with bone metastases (BMs) from RCC since bone represents an unfavorable site of metastasis for renal cell carcinoma (mRCC). Materials and methods: Data of patients with BMs from RCC were retrospectively collected. Age, sex, ECOG-Performance Status (PS), MSKCC group, tumor histology, presence of concomitant metastases to other sites, time from nephrectomy to bone metastases (TTBM, classified into three groups: 5 years) and time from BMs to skeletal-related event (SRE) were included in the Cox analysis to investigate their prognostic relevance. Results: 470 patients were enrolled in this analysis. In 19 patients (4{\%}),bone was the only metastatic site; 277 patients had concomitant metastases in other sites. Median time to BMs was 16 months (range 0 - 44y) with Median OS of 17 months. Number of metastatic sites (including bone, p = 0.01), concomitant metastases, high Fuhrman grade (p <0.001) and non-clear cell histology (p = 0.013) were significantly associated with poor prognosis. Patients with TTBM >5 years had longer OS (22 months) compared to patients with TTBM",
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T1 - Bone metastases in patients with metastatic renal cell carcinoma

T2 - Are they always associated with poor prognosis?

AU - Santoni, Matteo

AU - Conti, Alessandro

AU - Procopio, Giuseppe

AU - Porta, Camillo

AU - Ibrahim, Toni

AU - Barni, Sandro

AU - Guida, Francesco Maria

AU - Fontana, Andrea

AU - Berruti, Alfredo

AU - Berardi, Rossana

AU - Massari, Francesco

AU - Vincenzi, Bruno

AU - Ortega, Cinzia

AU - Ottaviani, Davide

AU - Carteni, Giacomo

AU - Lanzetta, Gaetano

AU - De Lisi, Delia

AU - Silvestris, Nicola

AU - Satolli, Maria Antonietta

AU - Collovà, Elena

AU - Russo, Antonio

AU - Badalamenti, Giuseppe

AU - Fedeli, Stefano Luzi

AU - Tanca, Francesca Maria

AU - Adamo, Vincenzo

AU - Maiello, Evaristo

AU - Sabbatini, Roberto

AU - Felici, Alessandra

AU - Cinieri, Saverio

AU - Montironi, Rodolfo

AU - Bracarda, Sergio

AU - Tonini, Giuseppe

AU - Cascinu, Stefano

AU - Santini, Daniele

PY - 2015

Y1 - 2015

N2 - Purpose: Aim of this study was to investigate for the presence of existing prognostic factors in patients with bone metastases (BMs) from RCC since bone represents an unfavorable site of metastasis for renal cell carcinoma (mRCC). Materials and methods: Data of patients with BMs from RCC were retrospectively collected. Age, sex, ECOG-Performance Status (PS), MSKCC group, tumor histology, presence of concomitant metastases to other sites, time from nephrectomy to bone metastases (TTBM, classified into three groups: 5 years) and time from BMs to skeletal-related event (SRE) were included in the Cox analysis to investigate their prognostic relevance. Results: 470 patients were enrolled in this analysis. In 19 patients (4%),bone was the only metastatic site; 277 patients had concomitant metastases in other sites. Median time to BMs was 16 months (range 0 - 44y) with Median OS of 17 months. Number of metastatic sites (including bone, p = 0.01), concomitant metastases, high Fuhrman grade (p <0.001) and non-clear cell histology (p = 0.013) were significantly associated with poor prognosis. Patients with TTBM >5 years had longer OS (22 months) compared to patients with TTBM

AB - Purpose: Aim of this study was to investigate for the presence of existing prognostic factors in patients with bone metastases (BMs) from RCC since bone represents an unfavorable site of metastasis for renal cell carcinoma (mRCC). Materials and methods: Data of patients with BMs from RCC were retrospectively collected. Age, sex, ECOG-Performance Status (PS), MSKCC group, tumor histology, presence of concomitant metastases to other sites, time from nephrectomy to bone metastases (TTBM, classified into three groups: 5 years) and time from BMs to skeletal-related event (SRE) were included in the Cox analysis to investigate their prognostic relevance. Results: 470 patients were enrolled in this analysis. In 19 patients (4%),bone was the only metastatic site; 277 patients had concomitant metastases in other sites. Median time to BMs was 16 months (range 0 - 44y) with Median OS of 17 months. Number of metastatic sites (including bone, p = 0.01), concomitant metastases, high Fuhrman grade (p <0.001) and non-clear cell histology (p = 0.013) were significantly associated with poor prognosis. Patients with TTBM >5 years had longer OS (22 months) compared to patients with TTBM

KW - Bone metastasis

KW - Prognostic factors

KW - Renal cell carcinoma

KW - Time to distant metastasis

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