The skeleton is one of the most common sites for metastasis in cancer, particularly breast and prostate cancers as well as multiple myeloma. Bone metastases usually result in fractures, bone pain, spinal cord compression, and hypercalcemia, with severe involvement of both quality of life and survival. Knowledge of pathogenetic mechanisms of bone metastases is thus essential to develop new molecular therapies targeting major factors involved in bone resorption.
|Translated title of the contribution||Bone metastases: Pathogenetic and clinical aspects|
|Number of pages||8|
|Publication status||Published - Feb 2010|
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical
- Medical Laboratory Technology