Bone mineral density changes in relation to environmental PCB exposure

Susan Hodgson, Laura Thomas, Elena Fattore, P. Monica Lind, Tobias Alfven, Lennart Hellström, Helen Håkansson, Grazia Carubelli, Roberto Fanelli, Lars Jarup

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Bone toxicity has been linked to organochlorine exposure following a few notable poisoning incidents, but epidemiologic studies in populations with environmental organochlorine exposure have yielded inconsistent results. Objectives: The aim of this study was to investigate whether organochlorine exposure was associated with bone mineral density (BMD) in a population 60-81 years of age (154 males, 167 females) living near the Baltic coast, close to a river contaminated by polychlorinated biphenyls (PCBs). Methods: We measured forearm BMD in participants using dual energy X-ray absorptiometry; and we assessed low BMD using age- and sex-standardized Z-scores. We analyzed blood samples for five dioxin-like PCBs, the three most abundant non-dioxin-like PCBs, and p,p'-dichlorophenyldichloroethylene (p,p'-DDE). Results: In males, dioxin-like chlorobiphenyl (CB)-118 was negatively associated with BMD; the odds ratio for low BMD (Z-score less than -1) was 1.06 (95% confidence interval, 1.01-1.12) per 10 pg/mL CB-118. The sum of the three most abundant non-dioxin-like PCBs was positively associated with BMD, but not with a decreased risk of low BMD. In females, CB-118 was positively associated with BMD, but this congener did not influence the risk of low BMD in women. Conclusions: Environmental organochlorine exposures experienced by this population sample since the 1930s in Sweden may have been sufficient to result in sex-specific changes in BMD.

Original languageEnglish
Pages (from-to)1162-1166
Number of pages5
JournalEnvironmental Health Perspectives
Volume116
Issue number9
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Polychlorinated Biphenyls
Bone Density
Dioxins
Environmental Exposure
Population
Photon Absorptiometry
Rivers
Forearm
Sweden
Poisoning
Epidemiologic Studies
Odds Ratio
Confidence Intervals
Bone and Bones

Keywords

  • Bone mineral density
  • p,p'-DDE
  • Polychlorinated biphenyls
  • Toxic equivalents

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Hodgson, S., Thomas, L., Fattore, E., Lind, P. M., Alfven, T., Hellström, L., ... Jarup, L. (2008). Bone mineral density changes in relation to environmental PCB exposure. Environmental Health Perspectives, 116(9), 1162-1166. https://doi.org/10.1289/ehp.11107

Bone mineral density changes in relation to environmental PCB exposure. / Hodgson, Susan; Thomas, Laura; Fattore, Elena; Lind, P. Monica; Alfven, Tobias; Hellström, Lennart; Håkansson, Helen; Carubelli, Grazia; Fanelli, Roberto; Jarup, Lars.

In: Environmental Health Perspectives, Vol. 116, No. 9, 09.2008, p. 1162-1166.

Research output: Contribution to journalArticle

Hodgson, S, Thomas, L, Fattore, E, Lind, PM, Alfven, T, Hellström, L, Håkansson, H, Carubelli, G, Fanelli, R & Jarup, L 2008, 'Bone mineral density changes in relation to environmental PCB exposure', Environmental Health Perspectives, vol. 116, no. 9, pp. 1162-1166. https://doi.org/10.1289/ehp.11107
Hodgson, Susan ; Thomas, Laura ; Fattore, Elena ; Lind, P. Monica ; Alfven, Tobias ; Hellström, Lennart ; Håkansson, Helen ; Carubelli, Grazia ; Fanelli, Roberto ; Jarup, Lars. / Bone mineral density changes in relation to environmental PCB exposure. In: Environmental Health Perspectives. 2008 ; Vol. 116, No. 9. pp. 1162-1166.
@article{521b5533d47f4f818198e5ba7f65cbbc,
title = "Bone mineral density changes in relation to environmental PCB exposure",
abstract = "Background: Bone toxicity has been linked to organochlorine exposure following a few notable poisoning incidents, but epidemiologic studies in populations with environmental organochlorine exposure have yielded inconsistent results. Objectives: The aim of this study was to investigate whether organochlorine exposure was associated with bone mineral density (BMD) in a population 60-81 years of age (154 males, 167 females) living near the Baltic coast, close to a river contaminated by polychlorinated biphenyls (PCBs). Methods: We measured forearm BMD in participants using dual energy X-ray absorptiometry; and we assessed low BMD using age- and sex-standardized Z-scores. We analyzed blood samples for five dioxin-like PCBs, the three most abundant non-dioxin-like PCBs, and p,p'-dichlorophenyldichloroethylene (p,p'-DDE). Results: In males, dioxin-like chlorobiphenyl (CB)-118 was negatively associated with BMD; the odds ratio for low BMD (Z-score less than -1) was 1.06 (95{\%} confidence interval, 1.01-1.12) per 10 pg/mL CB-118. The sum of the three most abundant non-dioxin-like PCBs was positively associated with BMD, but not with a decreased risk of low BMD. In females, CB-118 was positively associated with BMD, but this congener did not influence the risk of low BMD in women. Conclusions: Environmental organochlorine exposures experienced by this population sample since the 1930s in Sweden may have been sufficient to result in sex-specific changes in BMD.",
keywords = "Bone mineral density, p,p'-DDE, Polychlorinated biphenyls, Toxic equivalents",
author = "Susan Hodgson and Laura Thomas and Elena Fattore and Lind, {P. Monica} and Tobias Alfven and Lennart Hellstr{\"o}m and Helen H{\aa}kansson and Grazia Carubelli and Roberto Fanelli and Lars Jarup",
year = "2008",
month = "9",
doi = "10.1289/ehp.11107",
language = "English",
volume = "116",
pages = "1162--1166",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "9",

}

TY - JOUR

T1 - Bone mineral density changes in relation to environmental PCB exposure

AU - Hodgson, Susan

AU - Thomas, Laura

AU - Fattore, Elena

AU - Lind, P. Monica

AU - Alfven, Tobias

AU - Hellström, Lennart

AU - Håkansson, Helen

AU - Carubelli, Grazia

AU - Fanelli, Roberto

AU - Jarup, Lars

PY - 2008/9

Y1 - 2008/9

N2 - Background: Bone toxicity has been linked to organochlorine exposure following a few notable poisoning incidents, but epidemiologic studies in populations with environmental organochlorine exposure have yielded inconsistent results. Objectives: The aim of this study was to investigate whether organochlorine exposure was associated with bone mineral density (BMD) in a population 60-81 years of age (154 males, 167 females) living near the Baltic coast, close to a river contaminated by polychlorinated biphenyls (PCBs). Methods: We measured forearm BMD in participants using dual energy X-ray absorptiometry; and we assessed low BMD using age- and sex-standardized Z-scores. We analyzed blood samples for five dioxin-like PCBs, the three most abundant non-dioxin-like PCBs, and p,p'-dichlorophenyldichloroethylene (p,p'-DDE). Results: In males, dioxin-like chlorobiphenyl (CB)-118 was negatively associated with BMD; the odds ratio for low BMD (Z-score less than -1) was 1.06 (95% confidence interval, 1.01-1.12) per 10 pg/mL CB-118. The sum of the three most abundant non-dioxin-like PCBs was positively associated with BMD, but not with a decreased risk of low BMD. In females, CB-118 was positively associated with BMD, but this congener did not influence the risk of low BMD in women. Conclusions: Environmental organochlorine exposures experienced by this population sample since the 1930s in Sweden may have been sufficient to result in sex-specific changes in BMD.

AB - Background: Bone toxicity has been linked to organochlorine exposure following a few notable poisoning incidents, but epidemiologic studies in populations with environmental organochlorine exposure have yielded inconsistent results. Objectives: The aim of this study was to investigate whether organochlorine exposure was associated with bone mineral density (BMD) in a population 60-81 years of age (154 males, 167 females) living near the Baltic coast, close to a river contaminated by polychlorinated biphenyls (PCBs). Methods: We measured forearm BMD in participants using dual energy X-ray absorptiometry; and we assessed low BMD using age- and sex-standardized Z-scores. We analyzed blood samples for five dioxin-like PCBs, the three most abundant non-dioxin-like PCBs, and p,p'-dichlorophenyldichloroethylene (p,p'-DDE). Results: In males, dioxin-like chlorobiphenyl (CB)-118 was negatively associated with BMD; the odds ratio for low BMD (Z-score less than -1) was 1.06 (95% confidence interval, 1.01-1.12) per 10 pg/mL CB-118. The sum of the three most abundant non-dioxin-like PCBs was positively associated with BMD, but not with a decreased risk of low BMD. In females, CB-118 was positively associated with BMD, but this congener did not influence the risk of low BMD in women. Conclusions: Environmental organochlorine exposures experienced by this population sample since the 1930s in Sweden may have been sufficient to result in sex-specific changes in BMD.

KW - Bone mineral density

KW - p,p'-DDE

KW - Polychlorinated biphenyls

KW - Toxic equivalents

UR - http://www.scopus.com/inward/record.url?scp=54149089021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54149089021&partnerID=8YFLogxK

U2 - 10.1289/ehp.11107

DO - 10.1289/ehp.11107

M3 - Article

C2 - 18795157

AN - SCOPUS:54149089021

VL - 116

SP - 1162

EP - 1166

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 9

ER -