Bone mineral density in children, adolescents, and young adults with epilepsy

Giangennaro Coppola, Delia Fortunato, Gianfranca Auricchio, Ciro Mainolfi, Francesca Felicia Operto, Giuseppe Signoriello, Antonio Pascotto, Marco Salvatore

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The aim of this study was to assess bone mineral density (BMD) in a large population of children, adolescents, and young adults with epilepsy alone or in association with cerebral palsy and/or mental retardation. Methods: Ninety-six patients were enrolled in the study. The group comprised 50 males and 46 females, aged between 3 and 25 years (mean age 11 years). The control group consisted of 63 healthy children and adolescents (23 males, 40 females), aged between 3 and 25 years (mean age 12.1 years). Patients underwent a dual-energy x-ray absorptiometry (DEXA) scan of the lumbar spine (L1-L4) and the z scores were calculated for each patient; the t score was considered for patients 18 years of age or older. Results: Abnormal BMD was found in 56 patients (58.3%), with values documenting osteopenia in 42 (75%) and osteoporosis in 14 (25%). A significant difference emerged between epileptic patients and the control group in BMD, z score, and body mass index (BMI) (p =

Original languageEnglish
Pages (from-to)2140-2146
Number of pages7
JournalEpilepsia
Volume50
Issue number9
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Antiepileptic drugs
  • Bone mineral density
  • Osteopenia
  • Osteoporosis
  • Physical activity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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