TY - JOUR
T1 - Bone mineral density in children, adolescents, and young adults with epilepsy
AU - Coppola, Giangennaro
AU - Fortunato, Delia
AU - Auricchio, Gianfranca
AU - Mainolfi, Ciro
AU - Operto, Francesca Felicia
AU - Signoriello, Giuseppe
AU - Pascotto, Antonio
AU - Salvatore, Marco
PY - 2009/9
Y1 - 2009/9
N2 - Purpose: The aim of this study was to assess bone mineral density (BMD) in a large population of children, adolescents, and young adults with epilepsy alone or in association with cerebral palsy and/or mental retardation. Methods: Ninety-six patients were enrolled in the study. The group comprised 50 males and 46 females, aged between 3 and 25 years (mean age 11 years). The control group consisted of 63 healthy children and adolescents (23 males, 40 females), aged between 3 and 25 years (mean age 12.1 years). Patients underwent a dual-energy x-ray absorptiometry (DEXA) scan of the lumbar spine (L1-L4) and the z scores were calculated for each patient; the t score was considered for patients 18 years of age or older. Results: Abnormal BMD was found in 56 patients (58.3%), with values documenting osteopenia in 42 (75%) and osteoporosis in 14 (25%). A significant difference emerged between epileptic patients and the control group in BMD, z score, and body mass index (BMI) (p =
AB - Purpose: The aim of this study was to assess bone mineral density (BMD) in a large population of children, adolescents, and young adults with epilepsy alone or in association with cerebral palsy and/or mental retardation. Methods: Ninety-six patients were enrolled in the study. The group comprised 50 males and 46 females, aged between 3 and 25 years (mean age 11 years). The control group consisted of 63 healthy children and adolescents (23 males, 40 females), aged between 3 and 25 years (mean age 12.1 years). Patients underwent a dual-energy x-ray absorptiometry (DEXA) scan of the lumbar spine (L1-L4) and the z scores were calculated for each patient; the t score was considered for patients 18 years of age or older. Results: Abnormal BMD was found in 56 patients (58.3%), with values documenting osteopenia in 42 (75%) and osteoporosis in 14 (25%). A significant difference emerged between epileptic patients and the control group in BMD, z score, and body mass index (BMI) (p =
KW - Antiepileptic drugs
KW - Bone mineral density
KW - Osteopenia
KW - Osteoporosis
KW - Physical activity
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U2 - 10.1111/j.1528-1167.2009.02082.x
DO - 10.1111/j.1528-1167.2009.02082.x
M3 - Article
C2 - 19486359
AN - SCOPUS:69149098956
VL - 50
SP - 2140
EP - 2146
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 9
ER -